血浆置换治疗重型肝炎的时机选择及疗效观察  

Opportunity of plasma exchange for treating severe hepatitis and the observation of curative effect

作　　者：邓英[1] 符政远[1] 李勇忠[1] 聂晓红[1] 彭吉军[1] 胡文祥[1] 李淮[1] 王黔梅[1] 黄湘玲[1] 张丰伟[1] 

机构地区：[1]怀化市第一人民医院,湖南怀化418000

出　　处：《中国感染控制杂志》2004年第1期11-13,共3页Chinese Journal of Infection Control

摘　　要：目的　探讨应用血浆置换 (PE)治疗重型肝炎的疗效和治疗时机。方法　设观察组和对照组 ,两组在护肝综合治疗的基础上 ,观察组同时给予PE治疗。观察不同病期治愈好转率、总有效率 ,平均住院天数和主要实验室检查指标。结果　观察组 (76例 )重型肝炎早、中、晚期治愈好转率分别为 99.97% ,79.17% ,2 6 .32 % ,总有效率73.6 8% ;对照组 (4 5例 )分别为 6 5 % ,5 7.14 % ,9.0 9% ,总有效率 4 8.89% ;临床治愈病例平均住院时间 ,观察组为2 2 .5 2± 13.5 6d ,对照组为 5 2 .4 4± 18.2 5d ,两组比较 ,差异有显著性 (P <0 .0 0 1)。结论　PE是治疗重型肝炎较为安全有效的方法 ,重型肝炎患者宜在早、中期即用血浆置换治疗。Objective To evaluate the curative effect of plasma exchange (PE) for treating severe hepatitis. Methods Patients were divided into treated group and control group, both groups were given general treatment for protecting livers; and the treated group was given PE treatment simultaneously, recovering rates and total effective rates, average hospitalization days and major laboratory examination results were observed at different clinical stages. Results In the treated group, the recovering rates of severe hepatitis at early, middle and late stage were 99.97%, 79.17% and 26.32% respectively, and the total effective rate was 73.68%; in the control group were 65%, 57.14% and 9.09% respectively, and the total effective rate was 48.89%, the average hospitalization time of the clinical recovering cases in the treated and control group was 22.52± 13.56 days and 52.44± 18.25 days respectively. Conclusion PE provides a effective and safe way for treating severe hepatitis, it is quite suitable for the patients with severe hepatitis to be treated with PE at early and middle stages.

关 键 词：血浆置换 治疗 重型肝炎 PE 肝功能 

分 类 号：R575[医药卫生—消化系统] R457[医药卫生—内科学]