眼弓形虫病的临床及FFA和ICGA同步造影观察  

Clinical observation of simultaneous FFA and ICGA in ocular toxoplasmosis

作　　者：胡世兴[1] 阎宏[1] 魏湛云[2] 李梅[1] 谢楚芳[1] 林少春[1] 张悦[1] 

机构地区：[1]中山大学中山眼科中心,广州510060 [2]广州南方医院眼科

出　　处：《眼科研究》2003年第5期511-514,共4页Chinese Ophthalmic Research

基　　金：中山医科大学211工程资助项目(98171)

摘　　要：目的 探讨活动性眼弓形虫病(OT)的临床表现及眼底荧光血管造影(FFA)和吲哚菁绿血管造影(ICGA)的同步检查图像特征。方法 除临床检查外,对21例33眼活动性眼OT患者行眼底彩色照相,FFA和ICGA检查及血清抗体(单疱病毒、巨细胞病毒及抗弓形虫抗体)检测。结果 初诊5例为后部葡萄膜炎,16例为中心性渗出性视网膜脉络膜炎,但血清抗弓形虫抗体阳性。22眼见黄斑区瘢痕样改变,15眼瘢痕周围可见小片状出血。19眼FFA和ICGA均发现脉络膜新生血管(CNV)形成。结论 可致盲的活动性眼弓形虫病之临床表现无特异性;眼弓形虫感染可能是中心性渗出性视网膜脉络膜病变的病因之一,免疫因素可能参与了其发病过程;FFA和ICGA同步检查可增加CNV的检出率,给激光治疗提供定位依据。Objective To investigate the clinical manifestations and characteristics of active ocular toxoplasmosis (OT) by simultaneous examination of fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA). Methods FFA and ICGA were performed on the patients with active OT. Sera antibodies to Toxo,HSV and CMV were tested by enzyme linked immunosorbent assay. Results Twenty-one cases in this study primarily diagnosed as exudative central retinochoroiditis (16) and uveitis (5) showed positive or strong positive responses to toxoplasma antibodies and produced excellent therapeutic effect by anti-parasite medication. Of the total patients, 12 cases involved bilateral eyes and 9 unilateral. The experimental eyes showed acute exudative inflammatory reaction at the posterior area. 22 of them showed atrophic changes with scar-like formation at macular area. Dots and spots of hemorrhage around the scars were seen in 15 eyes. Choroidal neovascularization (CNV) was observed in 19 eyes by FFA and ICGA. Conclusion Few clinical specialties are evident for active ocular toxoplasmosis. Simultaneous examination of FFA and ICGA may improve confirmatory rate of CNV, providing localization for laser treatment.

关 键 词：眼弓形虫病 FFA ICGA 眼底荧光血管造影 吲哚菁绿血管造影 诊断 

分 类 号：R771.3[医药卫生—眼科]