奥沙利铂为主治疗消化道恶性肿瘤64例疗效分析  

Treatment Effect of Regimen Based on L-OHP in patients with Advanced Cancer in Digestive System

作　　者：毕明宏[1] 丁永为[1] 吴穷[1] 郑荣生[1] 秦凤展[1] 王洪亚[1] 

机构地区：[1]安徽省肿瘤医院肿瘤内科,233004

出　　处：《实用癌症杂志》2003年第6期638-640,共3页The Practical Journal of Cancer

摘　　要：目的　评价奥沙利铂联合甲酰四氢叶酸、氟脲嘧啶治疗晚期消化道恶性肿瘤的近期疗效和不良反应。方法　对 64例消化道恶性肿瘤患者 ,采用以奥沙利铂为主的方案进行化疗。奥沙利铂 13 0mg/m2 静脉滴注 2h ,第 1天 ;甲酰四氢叶酸 (FA )15 0mg/m2 静脉滴注 2h ,第 1～ 5天 ;5 氟脲嘧啶 3 0 0mg/m2 静脉滴注 4h ,第 1～ 5天。 3周重复 1次 ,至少化疗 2个周期后评价疗效 ,有效病例 4周后评定疗效。结果　共 64例患者 ,食管鳞癌 2 1例中 ,部分缓解 (PR ) 11例 ,有效率为 5 2 .4% ;胃腺癌 2 0例中 ,PR10例 ,有效率为 5 0 .0 % ;结直肠癌 2 3例中 ,完全缓解 (CR) 1例 ,PR 8例 ,有效率为 3 9.1%。不良反应主要为感觉神经毒性 ,骨髓抑制和胃肠道反应。结论　奥沙利铂为主的方案治疗晚期结直肠癌的疗效与国内外报告结果相似 ,对胃腺癌和食管鳞癌的治疗有较好疗效。不良反应轻 ,患者能耐受。Objective To evaluate the efficacy and adverse effects of Qxaliplatin(L-OHP) combined with 5-fluorouracil(5-Fu) and folinic acid(FA) in treatment of patients with advanced cancer in digestive system.Methods The patients were received L-OHP 130 mg/m 2(2-hour infusion) on day 1,combined with FA 150 mg/m 2(2-hour infusion),followed by 5-Fu 300 mg/m 2(4-hour infusion) on day 1-5,every 3 weeks.The treatment effect was assessed after at least 2 cycles and the response rates were determined 4 weeks later.Results There wer 64 cases of cancer in digestive system.The reponse rate(RR) were 52.4%(11/21) for esophagus cancer(PR:11 cases),50.0%(10/20) for stomach cancer(PR:10 cases),39.1%(9/23) for Colorectal cancer(CR:1 case,PR:8 cases).The main adverse effects were neurosensory toxicity,nausea,vomiting and myelosuppression.Conclusion It suggests that the regimen based on L-OHP is effective in the treatment of advanced colorectal cancer,as well as stomach cancer and esophagus cancer.It has mild adverse effect with good tolerability.

关 键 词：奥沙利铂 治疗 消化道恶性肿瘤 疗效分析 

分 类 号：R735[医药卫生—肿瘤]