Preparation and bio-distribution of bone tumor therapeutic radiopharmaceutical ^(153)Sm-TTHMP  

作　　者：JIANGShu-Bin LUOShun-Zhong LIUGuo-Ping DENGHou-Fu BINGWen-Zeng WANGWen-Jin WEIHong-Yuan HUShu 

机构地区：[1]InstituteofNuclearPhysicsandChemistry,ChinaAcademyofEngineeringPhysicsMianyang621900 [2]DepartmentofNuclearMedicineofFirstUniversityHospital,WestChinaMedicineCenter,SichuanUniversityChengdu610041

出　　处：《Nuclear Science and Techniques》2003年第2期123-126,共4页核技术（英文）

基　　金：Supported by CAEP Foundation(20020537)

摘　　要：TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were investigated. The results showed that weak basic media and high concentration ligands were favorable to form 153Sm-TTHMP; labeling compounds were stable at pH 7 in 7 days. The results also indicated that the chemical mole ratio of 153Sm-TTHMP is n(153Sm)﹕n(TTHMP) = 1﹕1 and skeleton uptake of 153Sm-TTHMP is high((13.96(3.51)%/g at 1h post injection and (13.54(2.98)%/g at 48h post injection), while the non-target tissue uptake is relatively low, so 153Sm-TTHMP is a promising bone tumor therapeutic agent.TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were investigated. The results showed that weak basie media and high concentration ligands were favorable to form 153Sm-TTHMP; labeling compounds were stable at pH 7 in 7 days. The results also indicated that the chemical mole ratio of 153Sm-TTHMP is n(153Sm) : n(TTHMP) = 1 : 1 and skeleton uptake of 153Sm-TTHMP is high((13.96±3.51)%/g at 1h post injection and (13.54±2.98)%/g at 48h post injection), while the non-target tissue uptake is relatively low, so 153Sm-TTHMP is a promising bone tumor therapeutic agent.

关 键 词：骨肿瘤 放射治疗 钐 ^153Sm-TTHMP 稳定性 

分 类 号：R738[医药卫生—肿瘤] R815[医药卫生—临床医学]