人防御素的研究进展  

Advances in the Research of Human Defensins

作　　者：彭力[1] 徐志南[1] 方向明[2] 吴金民[2] 岑沛霖[1] 

机构地区：[1]浙江大学生物工程研究所,杭州310027 [2]浙江大学医学院附属邵逸夫医院中心实验室,杭州310016

出　　处：《生物工程学报》2003年第3期261-266,共6页Chinese Journal of Biotechnology

基　　金：国家自然科学基金 (No.A3 0 0 70 85 4& 2 0 2 760 66);浙江省重点科技项目基金 (No.413 4910 3 0J3 0 0 0 70 0 110 3 2 41)资助~~

摘　　要：人防御素是近年发现的人体内重要的内源性抗生素 ,已引起国内外生物和医学研究者的日益重视。这里综述了人防御素的组织分布、分子生物学特点、作用机理、医学及药用价值等方面的研究进展 ,对采用基因重组方法生产人防御素的方法进行了评述 ,并展望了防御素的应用前景和发展趋势。Human defensin is a family of cationic antimicrobial peptides in human being. During the last two decades a series of endogenous α and β human defensins have been discovered. They are important components of the first barrier in human's body against the invasion of various microorganisms, and they are thought to play an important role in linking the innate and adaptive defense system of human being. The recent advances in the research of human defensins were reviewed, including their discovery, molecular and genetic properties, expression regulation, and mechanisms of antimicrobial activity. The possibility to produce human defensins via genetic engineering was also discussed. And the application outlook of human defensins in medicine and curing patients infected with antibiotics resistant microbials was presented.

关 键 词：抗菌肽 组织分布 分子生物学 作用机理 人防御素 

分 类 号：Q51[生物学—生物化学]