集束电极射频治疗肝癌患者后红细胞免疫功能和血清IL-2含量的变化  

Changes in erythrocyte immune functions and soluble Interleukin-2 in patients with PHC after radiofrequency ablation

作　　者：汪东文[1] 马庆久[2] 杜锡林[2] 贺舜民 高德明[2] 鲁建国[2] 

机构地区：[1]武警湖南省总队医院外一科,湖南长沙410006 [2]第四军医大学唐都医院普通外科,陕西西安710038

出　　处：《中国现代医学杂志》2004年第2期67-69,共3页China Journal of Modern Medicine

摘　　要：目的　研究原发性肝癌患者集束电极 (多弹头 )射频治疗前后红细胞免疫功能和血清IL - 2含量的变化。方法　采用郭峰免疫黏附酵母菌花环法和ELISA双抗体夹心法 ,检测 4 0例原发性肝癌患者治疗前后的红细胞免疫功能的改变和血清IL - 2含量的变化 ,并与健康对照组比较。结果　肝癌组治疗前RBC -C3bRR降低 ,RBC -CR增高 ,血清IL - 2含量降低 ,与对照组比较均有显著性差异 (P <0 .0 1)。治疗后RBC -C3bRR升高 ,RBC -ICR降低 ,血清IL - 2含量增高 ,治疗前后比较有非常显著性差异 (P <0 .0 1)。结论　集束电极 (多弹头 )射频治疗原发性肝癌患者可提高其红细胞的免疫功能和血清IL - 2含量 ,增强其机体免疫功能。检测原发性肝癌患者的红细胞免疫功能和血清中IL - 2含量 ,对了解病情程度、判断病人预后及指导综合治疗有一定价值。Objective: To observe the changes of erythrocyte immune functions and soluble Interleukin-2 in patients with PHC before and after radiofequency ablation and evaluate their clinical significance.Methods: ”Guofeng Methods” and sandwich ELISA were used to measure the changes of erythrocyte immunity and soluble Interleukin-2 before and after radiofrequency ablation in 40 PHC patient and compared them with the health control group.Results:The RBC-C3bRR and IL-2 in PHC patients before therapy were lower(P<0.01) while RBC-ICR was higher (P<0.01) than those of health control group. After therapy, the RBC-C3bRR and IL-2 elevated while RBC-ICR declined and all had significant difference compared with those before therapy (P<0.01).Conclusions:Rodiofr equency ablation can enhance the erythrocyte immune functions and IL-2 in patients with PHC, and play an important role in the antitumer effect. Measuring the analyzing the RBC immunity, T lymphocytes subsets and IL-2 are helpful to evaluate the immune state, therefore estimating the prognosis and directing modality.

关 键 词：原发性肝癌 射频治疗 红细胞免疫功能 白介素一2 

分 类 号：R735.7[医药卫生—肿瘤]