氩氦靶向治疗对肺癌细胞的灭活作用  

The Deactivation of Lung Cancer Cells by Targeted Ar-He Cryoablation

作　　者：王洪武[1] 刘静[2] 段蕴铀[1] 杨平地[3] 黄友章[3] 张燕群[4] 周一欣[2] 冯华松[1] 颜霞[1] 陆海英[1] 

机构地区：[1]海军总医院氩氦刀肿瘤治疗中心,北京100037 [2]中国科学院理化技术研究所低温中心,北京100080 [3]海军总医院血液科 [4]海军总医院影像中心

出　　处：《海军总医院学报》2003年第2期68-72,共5页Journal of Naval General Hospital of PLA

摘　　要：目的 研究体内、外氩氦靶向治疗对肺癌细胞的灭活作用。方法 观察氩氦刀对体外培养的肺癌细胞、实验动物及肺癌患者,治疗前后温度响应曲线、病理等方面的变化。结果 体外实验发现氩氦刀在空气 及水中均有快速降温及升温作用,在水中能快速形成冰球及融化冰球。氩氦刀对体外培养的肺癌细胞有明显的破坏作用,在人体中也证实能灭活肺癌细胞,在1个月内,肿瘤细胞呈凝固性坏死,在3个月后则被纤维组织代替。动物实验可见,氩氦刀在肌肉组织中快速形成冰球。结论 氩氦刀有快速升、降温作用,体内、外均能灭活肺癌细胞。Objective To study the deactivation of lung cancer cells by targeted Ar-He cryosurgical system. Methods The cryoprobe temperature and iceball formation were observed in air, water and rabbit liver during cryosurgery. The further study focused on postcryopathology in vitro cultured lung cancer cells and biopsy from patients. Results The temperature changed rapidly down to - 130℃ in 5 seconds in the probe tip during cryotherapy and iceball formed in a short time in water and rabbit liver. And the iceball could be melt in a short time when Helium was working. The lung cancer cells could be destroyed not only in vitro but also in patients. Coagulation necrosis could be found in less 1 month and lesion fi-brosis in more than 3 months post cryoablation in patients with lung cancer. Conclusion Targeted Ar-He cryosurgical system was proved to decrease and increase temperature immediately in the tip of cryoprobe. Iceball could be found in water, rabbit liver and lung mass. Pathologically, lung cancer cells could be deactivated by Ar-He cryotherapy.

关 键 词：氩氦靶向治疗系统 肺癌 

分 类 号：R734.2[医药卫生—肿瘤] R817[医药卫生—临床医学]