羊膜植入技术在青光眼手术中的应用  

Amniotic membrane implantation in trabeculectomy and non-penetrating deep sclerectomy

作　　者：杨静[1] 张纯[1] 王薇[1] 

机构地区：[1]北京大学第三医院眼科北京大学眼科中心,100083

出　　处：《中国实用眼科杂志》2003年第12期891-894,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的 :观察小梁切除联合羊膜植入术及非穿透深层巩膜切除联合羊膜植入术治疗青光眼的临床疗效。方法 :对 40例闭角型青光眼 5 5只眼和 3 3例开角型青光眼 44只眼两组病例分别进行常规小梁切除术及非穿透深层巩膜切除术 ,并在巩膜瓣下植入保存羊膜。观察术后眼压、视野、视力、超生生物显微镜 (UBM )等情况。进行术前术后对比 ,并随访 12～2 8月 ,平均随访 2 0月 ,观察术后疗效。结果 :两组病例术后与术前眼压对比 ,均有降低 ,有显著性差异 ,P <0 0 1。视野及视力保持不变或改善 ,UBM检查可见羊膜形态。随访期间眼压、视野及视力维持良好 ,手术有效率分别为 98 18%和 95 45 %。未出现不良反应。结论 :小梁切除联合羊膜植入术及非穿透深层巩膜切除联合羊膜植入术可较好的防止术后组织瘢痕形成 ,是安全、经济、有效地治疗青光眼的新方法。Objective:To evaluate the application of amniotic membrane in trabeculectomy and non-penetrating deep sclerectomy. Preserved amniotic membrane was underlaid the scleral flap of trabeculectomy in 55 eyes of 40 patients with primary angle closure glaucoma (PACG) and non-penetrating deep sclerectomy (NPDS) in 44 eyes of 33 patients with primary open angle glaucoma (POAG),respectively.Intraocular pressure (IOP),visual field,vision acuity and ultrasound biomicroscopy (UBM) were detected pre-or post-operations.The patients were followed up for 12～28 months (average 20 months). Results:The amniotic membrane could be observed by using UBM until 2 months after the operation.The success rates of two operation groups were 98.18% and 95.45%,respectively,without any special side effect. Conclusions:The results implied that amniotic membrane implantation in trabeculectomy and non-penetrating deep sclerectomy may play some roles in anti-fibrosis of filtering pathway after surgery and seems a simple,safe and effective procedure of anti-glaucoma operations.

关 键 词：青光眼 手术治疗 小梁切除术 羊膜植入术 非穿透深层巩膜切除术 

分 类 号：R775[医药卫生—眼科] R779.6[医药卫生—临床医学]