积雪草总苷对小鼠抑郁行为和脑内氨基酸含量的影响  

Effect of Total Triterpenes from Centella asiatica on the Depression Behavior and Concentration of Amino Acid in Forced Swimming Mice

作　　者：陈瑶[1] 韩婷[1] 秦路平[1] 芮耀诚[1] 郑汉臣[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中药材》2003年第12期870-873,共4页Journal of Chinese Medicinal Materials

基　　金：军队"十五"指令性课题资助项目(01L058 );上海联合利华研究与发展基金(9802)

摘　　要：目的:采用小鼠强迫游泳抑郁症模型,观察积雪草总苷的抗抑作用。;方法:昆明种小鼠随机分为空白对照组、模型组、阳性对照丙咪嗪组和积雪草总苷组,分析药物对小鼠强迫游泳不动时问及脑内氨基酸含量的影响结果:丙咪嗪组和积雪草总苷低、中、高3个剂量能够显著缩短小鼠强迫游泳不动时间,改善强迫游泳所致小鼠脑内氨基酸含量的失调。结论:积雪草总苷具有抗抑郁活性。Objetive: To evaluate the antidepressant activity of total triterpenes from Centella asiatica in forced swimming test. Methods: Mice were randomly divided into control group, model group and treatment group. The effect of total triterpenes from Centella asiatica on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed. Results: Imipramine and total triterpenes from Centella asiatica reduced the immobility time and ameliorated the imbalance of amino acid levels. Conclusion:The total triterpenes from Centella asiatica had antidepressant activity.

关 键 词：积雪草总苷 抑郁症 氨基酸 动物实验 治疗机理 中药 

分 类 号：R277.794[医药卫生—中医学]