FcγRⅢB基因、G2m(23)因子与侵袭性牙周炎的研究  

Relevance of FcγRⅢb genotype, IgG G2m(23) factor to the susceptibility of aggressive periodontitis

作　　者：张华湘[1] 谢昊[1] 任铁冠[1] 

机构地区：[1]武汉大学口腔医学院牙周科,430079

出　　处：《中华口腔医学杂志》2003年第2期129-131,共3页Chinese Journal of Stomatology

基　　金：湖北省青年基金资助项目 ( 98B0 2 1)

摘　　要：目的　探讨中性多形核白细胞 (polymorphonuclearneutrophils ,PMNs)表面FcγRⅢb受体遗传多态性及人类免疫球蛋白G重链遗传标记因子 G2m(2 3)因子与侵袭性牙周炎的关系。方法　侵袭性牙周炎患者 2 1例 ,健康对照 2 6名 ,提取静脉血基因组DNA及血清 ,分别用PCR和免疫斑点的方法测定FcγRⅢb基因型和G2m(2 3)因子。结果　侵袭性牙周炎患者FcγRⅢBNA1 /NA1基因型检出率高于健康对照 (P <0 0 5) ;侵袭性牙周炎患者中FcγRⅢb基因型为NA1 /NA1 ,并且G2m(2 3)阳性的个体比率比健康对照组高 (P <0 0 5) ;G2m(2 3)因子在侵袭性牙周炎患者与健康对照组中的分布差异无显著性。结论　FcγRⅢBNA1 /NA1基因可能是中国人侵袭性牙周炎的易感基因 ;FcγRⅢb基因型为NA1 /NA1 ,G2m(2 3)Objective To investigate the polymorphism of FcγRⅢb genotype, IgG G2m(23) factor and their associations with the susceptibility to aggressive periodontitis Methods DNA of white blood cells and serum from 21 aggressive periodontitis patients and 26 healthy controls was extracted Genotype of FcγRⅢb and phenotype of G2m(23) factor was determined by allele specific PCR and dot immunobinding assay respectively Results The frequency of FcγRⅢb NA1/NA1 genotype in aggressive periodontitis patients was significantly higher than in healthy controls ( P <0 05) The ratio of subjects with FcγRⅢb NA1/NA1genotype and positive G2m(23) factor was higher in aggressive periodontitis patients(11/21) than in health controls(5/26) ( P <0 05). However, no statistical difference in distribution of G2m(23) factor alone was observed between patients and controls Conclusions This study indicates that FcγRⅢb NA1/NA1 genotype may be a susceptible genotype to aggressive periodontitis in Chinese population Subjects with FcγRⅢb NA1/NA1 genotype and positive G2m(23) factor may be more susceptible to aggressive periodontitis

关 键 词：牙周炎 遗传易感性 受体 中性多形核白细胞 FcγRⅢB基因 

分 类 号：R781.42[医药卫生—口腔医学]