p16蛋白在甲状腺癌组织表达及临床意义的关系  

Clinical significance on the expression of p16 protein in thyroid carcinoma

作　　者：林方才[1] 高庆云[1] 陈瑞新[2] 张德恒[2] 

机构地区：[1]北京电力医院外科,北京100073 [2]白求恩医科大学第三临床学院外科,吉林长春130031

出　　处：《耳鼻咽喉（头颈外科）》2003年第4期239-241,I004,共4页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：目的 探讨p16蛋白表达在甲状腺癌发生、发展中的作用及其临床意义。方法采用免疫组织化学SP法检测p16蛋白在甲状腺癌组织中的表达或缺失。结果p16蛋白在甲状腺乳头癌和甲状腺滤泡癌组织中的表达率明显高于甲状腺髓样癌和未分化甲状腺癌组织的表达率(P<0.05)。Ⅰ期p16蛋白的表达率明显高于Ⅲ、Ⅳ期(P<0.05)。无淋巴结转移组p16蛋白的表达率(92.6％)高于有淋巴结转移组(64.7％)(P<0.05)。高分化组p16蛋白的表达率(90.3％)高于低分化组(61.5％)(P<0.05)。结论p16蛋白参与了甲状腺癌的发生和发展,与甲状腺癌的临床分期、分化程度、淋巴结转移有关,可作为临床判定预后的参考指标之一。Objective To study the relationship berween expression of p16 protein and the biological be- havior of thyroid carcinoma. Methods The expression of p!6 protein of thyroid carcinoma was examined by im-munohistochemical staining technique (SP method). Results The positive rate of p16 protein expression in papillary thyroid carcinoma (PTC ) and follicular thy-roid carcinoma (FTC) was significantly higher than that in medullary thyroid carcinoma (MTC ) and undif-ferentiated carcinoma (UDC) ( P< 0.05). The positive rate ofp16 protein expression in the stage I of thyroid carcinoma was obviously higher than that in III and IV stage (P <0.05). The Ievel of p!6 in the non-lymph node in-vasion group (92.6% ) was higher than that in lymph node invasion group (64.7% ) (P <0.05 ) . The positive rate of p16 (90.3%) in the well differentiated group in PTC and FTC was higher than that in poorly differentiated group (61.5% ) (P <0.05) . Conclusion The p16 protein may take part in pathogenesis and differentiation ofthyroid carcinoma. p 16 protein expression is could be associated with differential degree, lymph node invasion and clinical stages of thyroid carcinoma.

关 键 词：P16蛋白 甲状腺癌 癌组织 免疫组织化学 临床分期 预后 

分 类 号：R736.1[医药卫生—肿瘤]