原发性肝癌的遗传学研究  

A STUDY ABOUT THE GENETIC OF PRIMARY HEPATOCELLUAR CARCINOMA

作　　者：梁争论[1] 门伯媛[1] 徐慧文[1] 刘蓬勃[1] 

机构地区：[1]西安医科大学流行病学教研室,西安710061

出　　处：《西安医科大学学报》1992年第1期8-11,共4页Journal of Xi'an Medical University(Chinese)

基　　金：1987年国家自然科学基金

摘　　要：本文对74例原发性肝癌病人和相应的75例对照进行了HLA检测和遗传度调查。结果表明:肝癌组与对照组相比,Bw39抗原频率明显升高(Fisher P<0.01,Pc>0.05);而Bw60、Bw35抗原频率明显下降(Fisher P<0.01,Pc>0.05)。从群体遗传学调查证明了遗传因素在肝癌发病中的作用。74 primary hepatocellular carcinoma patients (PHC) and 75 controls are tested for HLA and investigated heritability. The results showed the frequency of Bw39 antigen was significantly higher in PHC patients than that in the controls. (Fisher P<0.01, Pc>0.05); but the frequeney of Bw60 antigen, was lower (Fisher P<0.05, Pc>0.05 ). The result of heritability proved the role ofgenetic factor in PHC development.

关 键 词：遗传因素 HLA 遗传度 肝肿瘤 

分 类 号：R735.702[医药卫生—肿瘤]