益气养血保元方中微量元素对肝癌细胞的影响  

EFFECT OF OQP ON CELL STRAIN OF HUMAN HEPATIC CARCINOMA SMMC-7721

作　　者：任瑛云 张玉五[2] 薛颖[2] 兰和楼[3] 

机构地区：[1]西安医科大学中西医结合研究所,西安710061 [2]西安医科大学第一附属医院中医学教研室 [3]西安医科大学制药厂

出　　处：《西安医科大学学报》1992年第2期144-147,共4页Journal of Xi'an Medical University(Chinese)

摘　　要：本实验通过益气养血保元方(OQP)对肝癌SMMC-7721细胞的作用,看到OQP可抑制肝癌细胞~3H-TdR和^(14)C-UR的掺入率,二者间有随OQP剂量增大而抑制率升高的剂量效应关系,提示OQP影响了肝癌SMMC-7721细胞的DNA、RNA合成,直接影响了癌细胞的生长分化,这些作用,可能是通过OQP中低Cu/Zn比值,高硒含量而达到的。临床证实OQP可改善中、晚期肝癌病人一般状况,恢复放疗、化疗病人白血球外,可能对肝癌细胞还有直接抑制生长分化的作用。The effect of OQP, a pormula of traditional Chinese medieine belonging to the category 'Precription of the Reinforeing Qi and Enriching Blood for keep the Original Qi', on cell strain of human hepatic carcinoma SMMC-7721 was observed. The results showed that OQP depressed the incorporation of both ~3H-TdR and ^(14)C-UR in cells of hepatic carcinoma. This indicated that OQP inhibited the synthesis of DNA and RNA, and the growth of the cancer cell. Such effect may result from the low ratio Cu/Zn and the high content of Se in OQP. In conclusion, in this study it has been demonstrated that OQP can not only improve the general condition of patients in advanced liver cancer and lcukopenia of patients in chemotherapy and radiotherapy, but also can inhibite the growth of the cell of hepatic carcinoma directly.

关 键 词：益气养血保元方 微量元素 肝肿瘤 

分 类 号：R735.705[医药卫生—肿瘤]