复发性口疮患者血液中SOD活性与Zn、Cu、Fe含量检测  

Detection of SOD activity and trace elements in the blood of RAU patient

作　　者：季旭东[1] 石晶[1] 韩冰[1] 曲旭红[1] 石爱梅[1] 

机构地区：[1]郑州大学第一附属医院口腔科,郑州450052

出　　处：《郑州大学学报（医学版）》2004年第1期102-104,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的 :研究复发性口疮 (RAU)患者血液中超氧化物歧化酶 (SOD)活性及微量元素 (TE)的变化。方法 :用Disilvestro方法测定 5 0例复发性口疮患者及 5 0例正常人血清中的SOD活性 ,用光谱分析仪测定锌 (Zn)、铜 (Cu)、铁(Fe)含量并加以比较。结果 :复发性口疮患者血液中SOD活性 ((1 7.1 3± 2 .2 6 )u/ml)较正常人 ((2 1 .0 8± 1 .4 6 )u/ml)明显降低 (P <0 .0 1 ) ,血清中Zn((0 .71 2 7± 0 .0 6 98)mg/L)、Fe((1 .0 2 91± 0 .1 2 1 6 )mg/L)含量低于正常人Zn((0 .96 39± 0 .1 2 93)mg/L)、Fe((1 .2 85 8± 0 .1 2 71 )mg/L)含量 (P <0 .0 1 ) ,Cu的含量与正常人差异无统计学意义(P >0 .0 5 )。结论 :在RAU的发病过程中SOD活性及Zn、Fe含量低下可能是RAU多因素致病环节 ,可提高SOD活性和适当补充锌。Aim: To investigate the changes of SOD activity, trace elements (Zn, Cu, Fe) in blood of patients with recurrent aphthous ulcer (RAU). Methods: The contents of Zn, Cu, and Fe, and SOD activity in the blood were measured in 50 RAU patients and 50 healthy controls. Results: The SOD activity in RAU patients was lower than that of normal controls ((17.13±2.26) u/ml vs. (21.08±1.46) u/ml, P <0.01). The serum Zn and Fe in RAU patients were lower than that in normal subjects ((0.712 7±0.069 8) mg/L vs (0.963 9±0.129 3) mg/L for Zn; (1.029 1±0.121 6) mg/L vs (1.285 8±0.127 1) mg/L for Fe P <0.01). There was no significant difference between the RAU patients and normal subjects in the content of Cu. Conclusion: Reduced SOD activity and lower contents of Zn and Fe could happen in RAU. Increasing the SOD activity and taking in trace elements might be effective in the treatment of RAU.

关 键 词：复发性口疮 超氧化物歧化酶 微量元素 

分 类 号：R781.5[医药卫生—口腔医学]