微血管密度和血管内皮生长因子与大肠癌肝转移的关系研究  

Study on nncrovessel density and vascular endothelial growth factor in colorectal caranoma vnth postoperative liver metastasis

作　　者：侯健[1] 樊峰[1] 高敏[2] 

机构地区：[1]苏州市第二人民医院普外科,215002 [2]苏州大学附属第一人民医院普外科,215006

出　　处：《中国肿瘤临床与康复》2003年第6期489-491,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的研究微血管密度(MVD)和血管内皮生长因子(VEGF)与大肠癌术后发生肝转移的关系。方法检测160例大肠癌标本中VEGF、和MVD的表达并结合随访结果。结果 VEGF、和MVD与大肠癌的临床分期密切相关:Duke C期的vEGF和MVD表达高于B期,差异有显著性(p<0.01);术后发生肝转移组VEGF和MVD表达高于无转移组,差异有显著性(P<0.01)。结论检测大肠癌病灶中MVD和VEGF的表达能预测患者的临床分期,MVD和VEGF过度表达的患者,术后发生肝转移的危险性大。Objective To study the relation between microvessel density ( MVD), vascular endothelial growth factor (VEGF) and postoperative liver metastasis of colorectal cancer. Methods Microvessel density and vascular endothelial growth factor were measured in 160 patients with colorectal cancer. Results Higher levels of VEGF and MVD were significantly correlated with Dukes stage. The levels of VEGF and MVD in primary colorectal cancer in Dukes stage C were significantly higher than those in Dukes stage B(P<0.01). Higher levels of VEGF and MVD were significantly correlated with the rate of postoperative hepatic metastasis( P < 0.01). Conclusion Examination of VEGF and MVD in colorectal cancer has important clinical significance for more accurately evaluating the prognosis. High levels of VEGF and MVD may be involved in patients with postoperative hepatic metastasis.

关 键 词：结直肠肿瘤 微血管密度 血管内皮生长因子 肝转移 大肠癌 

分 类 号：R735.32[医药卫生—肿瘤] R730.4[医药卫生—临床医学]