癫痫持续状态患者血及脑脊液神经特异性烯醇化酶含量的变化及Mg^(2+)的影响  

The Changes of neuron-specific enolase in blood and cerebrospinal fluid of patients with status epilepticus and the effect of Mg^(2+)

作　　者：刘学伍[1] 迟兆富[1] 尚伟[2] 王慧煜[1] 于美娟[1] 吴伟[1] 庞琦[2] 

机构地区：[1]山东大学齐鲁医院神经内科,山东济南250012 [2]山东大学第二医院神经科,山东济南250033

出　　处：《中风与神经疾病杂志》2003年第3期253-255,共3页Journal of Apoplexy and Nervous Diseases

基　　金：山东省自然科学基金资助项目 (Y2 0 0 1C10 )

摘　　要：目的　探讨癫痫持续状态 (SE)患者血及脑脊液神经特异性烯醇化酶 (NSE)的含量变化 ,并观察Mg2 + 的作用。方法　将 40例SE患者分为 2组 :常规治疗组 2 0例 ,给予地西泮 1 0～ 2 0mg缓慢静注等常规综合治疗 ;Mg2 + 组 2 0例 ,辅助性应用硫酸镁治疗 ;两组患者在症状控制后 2 4h和 72h检查静脉血和脑脊液中NSE的含量。并分别与 2 0例非脑和脊髓病变的其它疾病患者 (无血和脑脊液NSE的异常 )作对照 (正常对照组 )。结果　正常对照组患者血和脑脊液NSE的含量分别为 9.1 1± 3 .2 4 μg/L和 1 1 .32± 3 .2 2 μg/L ;常规治疗组在症状控制后 2 4h和 72h血中NSE含量平均为 2 9.76± 6 .77μg/L和 2 6 .72± 5 .39μg/L ,均较对照组明显增加 (P <0 .0 1 ) ,脑脊液NSE平均为34 .31± 7.64μg/L和 31 .84± 6 .41 μg/L ,均较对照组明显增加 (P <0 .0 1 ) ;Mg2 + 组在症状控制后 2 4h和 72h血NSE平均为 1 6 .68± 3 .31 μg/L和 1 1 .35± 5 .68μg/L ,与常规治疗组比较均P <0 .0 1 ,与正常对照组比较在 2 4h时差异较显著(P <0 .0 5) ,72h时差异不显著 (P >0 .0 5) ;脑脊液NSE平均为 1 8.63± 6 .2 0 μg/L和 1 3 .94± 6 .2 3μg/L ,与常规治疗组比较差异均显著 (P <0 .0 5) ,与正常对照组比较在 2 4h时差异较显?Objective To detect the Changes of neuron specific enolase in blood and cerebrospinal fluid of patients with status epilepticus(SE) and the effect of Mg 2+ . Methods 20 cases of status epilepticus were treated with a large dosage of magnesium sulfate,and compared with 20 cases of routine systemic methods and 20 cases of control group. Results The blood and cerebrospinal fluid NSE were mean of 9.11±3.24μg/L and 11.32± 3.22μg/L ;Whereas in the group of routine therapy the blood NSE were mean of 29.76±6.77μg/L and 26.72 ± 5.39μg/L ,at 24h and 72h after the symptoms were controlled. The NSE in CSF were 34.31 ± 7.64μg/L and 31.84 ± 6.41μg/L respectively. Whereas in the group of magnesium sulfate,the blood NSE were 16.68 ± 3.31μg/L and 11.35 ± 5.68μg/L ( P <0.01). The NSE in CSF were 18.63 ± 6.20μg/L ( P <0.05) and 13.94 ± 6.23μg/L ( P < 0.05 ). Conclusion The patiens with SE have increased NSE in blood and cerebrospinal fluid,existing obvious brain damage. We believed that the method of a large dose of magnesium sulfate could decrease the contents of NSE in blood and cerebrospinal fluid and abate the brain damage obviously.

关 键 词：癫痫持续状态 脑脊液 神经特异性烯醇化酶 硫酸镁 脑损害 神经保护剂 

分 类 号：R742.1[医药卫生—神经病学与精神病学]