抑肽酶佐治脑出血的临床研究  

Auxiliary treatment of aprotinin on cerebral hemorrhage:clinical observation

作　　者：孟令秋[1] 吴江[1] 周春奎[1] 

机构地区：[1]吉林大学第一医院神经内科,吉林长春130021

出　　处：《中风与神经疾病杂志》2003年第3期233-234,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　观察抑肽酶辅助治疗脑出血脑水肿的疗效及安全性。方法　收集脑出血患者 41例 ,分为 2组 ,抑肽酶治疗组 2 1例 ;对照组 2 0例。治疗前后进行神经功能评分 ,CT下测量水肿体积。结果　 (1 )入院后 1、2、3周用欧洲脑卒中量表进行神经功能评分 ,抑肽酶治疗组分值高于对照组 (P <0 .0 5)。 (2 )水肿产生量治疗组少于对照组 (P <0 .0 5)。结论　脑出血急性期加用抑肽酶可以抑制脑水肿的形成 ,提高脑出血患者神经功能评分 。Objective To observe the therapeutic effects of aprotinin on cerebral hemorrhage and cerebral edema. Methods 41 patients were divided into two groups:aprotinin treating group (21 cases)and control group(20 cases). The patients' neurologic function was marked according to the European Stroke Standards of Grading For Cerebral Attacking. The Volumes of edema were observed by CT in 10d through 14d after their attacks. Results The therapeutic effect on the aprotinin treating group was significantly better than that in the control group,while the producing of edema was significantly less than the control group. Conclusion Aprotinin can inhibit the formation of cerebral edema and improve neurologic function marks after attacks. It is better to use aprotinin simultaneously than to use mannitol only.

关 键 词：抑肽酶 脑出血 临床研究 神经功能 脑水肿 甘露醇 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R977.3[医药卫生—临床医学]