血管内皮生长因子和血管生成与胃癌发展的关系  被引量:9

Relationship of vascular endothelial growth factor and angiogenesis to the progression of gastric carcinoma

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作  者:骞爱荣[1] 赵俊生[2] 商澎[1] 赵建业[1] 陈建[2] 陈志南[1] 

机构地区:[1]第四军医大学基础部细胞工程研究中心,陕西西安710033 [2]兰州医学院病理学教研室,甘肃兰州730000

出  处:《第四军医大学学报》2003年第12期1100-1103,共4页Journal of the Fourth Military Medical University

摘  要:目的 :探讨血管内皮生长因子 (VEGF)和血管生成与胃癌发展的关系 .方法 :应用免疫组织化学方法 ,检测 10 2例人胃癌组织VEGF蛋白表达和微血管密度 (MVD) .分析VEGF和MVD及其与胃癌组织学分级、浸润深度、生长方式、淋巴结转移和预后的关系 .结果 :VEGF阳性表达率为4 9.1% ,VEGF阳性者MVD值显著高于阴性者 (P <0 .0 5 ) ,VEGF表达和MVD与胃癌淋巴结转移密切相关 (P <0 .0 5 ) ,而与组织学分级无关 ;VEGF表达还与胃癌浸润深度和生长方式密切相关 (P <0 .0 5 ) ;VEGF表达阳性或MVD≥ 5 0的胃癌患者 5a生存率较低 (P <0 .0 5 ) .结论 :VEGF与胃癌的血管生成密切相关 ,对胃癌的生长和浸润转移有促进作用 。AIM: To investigate the relationship of vascular endothelial growth factor (VEGF) and angiogenesis to the progression of gastric carcinoma (GC). METHODS: VEGF protein expression and microvessel density (MVD) in 102 cases of human GC were examined by using immunohistochemical staining. MVD and VEGF expression were analyzed together with their relations to histologic stage, depth of invasion, growth pattern and lymph node metastasis. RESULTS: MVD was significantly higher in VEGF positive GC cases than that in VEGF negative ones ( P <0.05 ). MVD and VEGF were positively correlated with lymph node metastasis ( P <0.05), but their relations to the histologic stage were not significant. VEGF was correlated with depth of invasion and growth pattern. The 5 year survival rate was significantly low in GC patients with positive expression of VEGF or MVD≥50 ( P <0.05). CONCLUSION: VEGF is highly related to angiogenesis of GC and promotes growth, invasion and metastasis of GC. VEGF or MVD is one of the predictors for the biological behavior of GC.

关 键 词:胃肿瘤 内皮生长因子 新生血管化 病理性 肿瘤转移 

分 类 号:R361.2[医药卫生—病理学]

 

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