Human protamines and the developing spermatid: their structure, function, expression and relationshipwith male infertility  

作　　者：Vincent W. Aoki Douglas T. Carrell 

机构地区：[1]Andrology and IVF Laboratories University of Utah School of Medicine, Salt Lake City, UT 84108, USA,Andrology and IVF Laboratories University of Utah School of Medicine, Salt Lake City, UT 84108, USA

出　　处：《Asian Journal of Andrology》2003年第4期315-324,共10页亚洲男性学杂志（英文版）

摘　　要：<abstract>During spermiogenesis, the protamine proteins play an integral role in spermatid chromatin compaction. Recent research has focused on many facets of protamine biology, including protamine gene and protein structure/ function relationships, mechanisms of protamine expression regulation and involvement of the protamines in male fertility. In this paper, we review our current understanding of the structure and function of the protamine-1 (P1) and protamine-2 (P2) proteins and genes, the expression and regulation of these genes and the relationship between the protamines and male fertility. In addition, we offer a brief outlook on future investigation into protamine proteins.<abstract>During spermiogenesis, the protamine proteins play an integral role in spermatid chromatin compaction. Recent research has focused on many facets of protamine biology, including protamine gene and protein structure/ function relationships, mechanisms of protamine expression regulation and involvement of the protamines in male fertility. In this paper, we review our current understanding of the structure and function of the protamine-1 (P1) and protamine-2 (P2) proteins and genes, the expression and regulation of these genes and the relationship between the protamines and male fertility. In addition, we offer a brief outlook on future investigation into protamine proteins.

关 键 词：protamines SPERMATIDS male infertility spermatid transition proteins 

分 类 号：R698.2[医药卫生—泌尿科学]