supported by the National Natural Science Foundation of China(Nos.31971415 and 32171492)。
The environmental presence of decabromodiphenyl ether(BDE-209),which is toxic to the male reproductive system,is widespread.The current study investigated its mechanism of toxicity in mice.The results showed,that BDE-...
supported by National Key R&D Program(2017YFA0103803);National Natural Science Foundation of China(31890784);National Key R&D Program(2016YFA0500903,2016YFA0503300).
Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro...
supported by the Genome Tagging Project and grants from the Chinese Academy of Sciences(XDB19010204);the Shanghai Municipal Commission for Science and Technology(17411954900);the National Natural Science Foundation of China(31530048,81672117 and31730062)
The Human Genome Project(HGP),launched in 1990 and finished in 2004,has not only provided the complete human genome sequence of more than 2.85 billion nucleotides and evidence of 20 000-25 000 protein-coding genes[1];...
Colloid centrifugation can be used to separate heterogeneous populations of cells particularly semen samples, which typically contain mixtures of spermatozoa at different stage of maturity together with dead and dying...
To illustrate the involvement of tubulobulbar complexes (TBC) in ubiquitin-proteasome degradation of unnecessary proteins in the head cytoplasm of late spermatids, the localization of polyubiquitin and proteasome was ...
Breast cancer resistance protein (Bcrp) is an ATP-dependent efflux drug transporter. It has a diverse spectrum of hydrophilic and hydrophobic substrates ranging from anticancer, antiviral and antihypertensive drugs,...
The mechanisms underpinning the latter stages of spermiogenesis are poorly understood and male germ cells have been presumed to extensively employ post-tran- scriptional regulatory machinery,
Aim: To understand the biological functions of the ectoplasmic specializations between Sertoli cells and maturing spermatids in seminiferous epithelia. Methods: In order to disrupt the function of the ectoplasmic sp...
Aim: To determine the effectiveness of the ski 1, sk9 and ski 1 TNUA5 Sertoli cell lines in binding germ cells in vitro. Methods: The immortalized Sertoli cell lines sk9, ski 1 and ski 1 TNUA5 were used in co-cultur...
During spermiogenesis, the protamine proteins play an integral role in spermatid chromatin compaction. Recent research has focused on many facets of protamine biology, including protamine gene and protein st...