局部亚低温对大鼠脑梗死体积和神经功能及血清神经元特异性烯醇化酶的影响  

The effect of local mild hypothermia on the cerebral infarction volume,neurologic function and the serum concentration of neuron-specific enolase in rats

作　　者：曹绪政[1] 苏志强[2] 徐建民[1] 兰杰[1] 邢济臣[1] 梁军[1] 

机构地区：[1]解放军第211医院神经内科,哈尔滨150080 [2]哈尔滨医科大学第一附属医院神经内科

出　　处：《中华物理医学与康复杂志》2003年第5期260-262,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　观察局部亚低温对缺血脑组织的保护作用。方法　制作大鼠大脑中动脉脑缺血模型 ,比较局部亚低温治疗与否对大鼠脑梗死灶体积、神经功能和血清神经元特异性烯醇化酶 (NSE)的影响。结果　亚低温组和常温组大鼠脑梗死体积分别为 (84.90± 11.3 6)和 (12 8.95± 13 .42 )mm3 ,神经功能评分分别为(0 .95± 0 .17)和 (1.60± 0 .2 4)分 ,血清NSE浓度分别为 (9.19± 3 .42 )和 (13 .5 5± 4.0 7)ng/ml ,差异均有显著性意义。结论　局部亚低温治疗对缺血脑组织具有保护作用。Objective To investigate the protective effect of local mild hypothermia on the ischemic cerebral tissues. Methods A model of middle cerebral artery occlusion was prepared in Wistar rats to compare the difference of the cerebral infarction volume and neurologic function and the serum concentration of neuron-specific enolase (NSE) between the local mild hypothermia group and the normal temperature group. Results It was found that the cerebral infarction volume was 84.90±11.36 and 128.95±13.42 mm 3 in the local mild hypothermia group and the normal temperature group, the neurologic function score 0.95±0.17 and 1.60±0.24, and the serum concentration of NSE 9.19±3.42 and 13.55±4.07ng/ml,respectively. The differences between the two groups were statistically significant. Conclusion The findings of this study suggest that the local mild hypothermia treatment exerted protective effect on the ischemic neurons.

关 键 词：局部亚低温 脑梗死体积 神经功能 血清神经元 特异性烯醇化酶 

分 类 号：R743.33[医药卫生—神经病学与精神病学]