环氧化酶-2的表达与乳腺癌生物学行为的相关性  

Relation between COX-2 expression and biologic behavior of breast cancer

作　　者：韩正祥[1] 张敬川[1] 王琳[2] 张大红[2] 李庆明[2] 

机构地区：[1]徐州医学院肿瘤学教研室,江苏徐州221002 [2]徐州医学院组织胚胎学教研室,江苏徐州221002

出　　处：《徐州医学院学报》2004年第1期32-34,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的　探讨环氧化酶 -2 (cyclooxygenase -2 ,COX -2 )的表达与乳腺癌发生、发展的关系。方法　应用免疫组织化学染色SABC法 ,检测 3 2例乳腺癌组织及相应癌旁正常腺体中COX -2蛋白的表达情况。结果　 3 2例乳腺癌组织中COX -2表达阳性率为 71.9% (2 3 /3 2 ) ,相应癌旁组织阳性率为 12 .5% (4/3 2 ) ,两者比较差异有显著意义 (P <0 .0 5)。不同年龄、原发肿瘤大小、淋巴结转移状况、TNM分期、病理类型以及激素受体状况时乳腺癌组织COX -2表达的差异均无显著性 (P >0 .0 5)。结论　COX -2高表达于乳腺癌组织中 ,其表达在乳腺癌的发生中可能具有重要意义 。ObjectiveTo study th e relation between cyclooxygenase-2 (COX-2) expression and the biologic behavi ors of breast cancer.?MethodsThe expression of COX-2 pr otein was detected in the cancer tissue and adjacent normal-appearance breast ep ithelium from 32 cases of breast cancer by immunohistochemistry.?Res ultsThe rate of positive COX-2 expession was 71.9% for breast cance r tissue, significantly higher than that for the adjacent normal breast epithel ia (12.5%). The COX-2 protein expression was not correlated with the clinical pa rameters: such as patient′s age, size of primary tumor, lymph node metastasis, P-TNM stage, pathologic type and hormone receptor status(P>0.05).?ConclusionCOX-2 overexpression may play a crucial role in the c arcinogenesis of humam breast cancer, but is not relevant to the other biologic behaviors of the cancer.

关 键 词：乳腺癌 环氧化酶-2 免疫组织化学 肿瘤发生 

分 类 号：R737.9[医药卫生—肿瘤]