芍药苷药理作用研究新进展  

New progress in pharmacological action of paeoniflorin

作　　者：张育贵 张淑娟 边甜甜[1,2] 司昕蕾 牛江涛 辛二旦[1,2] 王文顺 李越峰 ZHANG Yu-gui;ZHANG Shu-juan;BIAN Tian-tian;SI Xin-lei;NIU Jiang-tao;XIN Er-dan;WANG Wen-shun;LI Yue-feng(GanSu University of Chinese Medicine,Lanzhou 730000,China;Gansu Key Laboratory of Standard and Quality of Chinese Medicine Research,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中药质量与标准研究重点实验室,甘肃兰州730000

出　　处：《中草药》2019年第15期3735-3740,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81460611);甘肃省自然科学基金创新基地和人才计划项目(18JR3RA197);甘肃省中药质量与标准研究重点实验室开放基金(ZYZL18-008)

摘　　要：芍药苷是中药芍药和牡丹的主要有效成分,大量研究证明芍药苷具有抗抑郁、抗炎、镇痛、抗肿瘤、保肝、保护神经、调节免疫、镇静催眠等多种药理作用。截止目前,芍药苷极少以单体的形式应用于临床。通过查阅国内外近3年的文献,对芍药苷药理作用研究新进展进行梳理和总结,探讨其与中药复方药效关系,为芍药苷的进一步开发和临床应用提供参考。Paeoniflorin is the main effective component of Paeoniae lactiflora and Paeonia suffruticosa.A large number of studies have proven that paeoniflorin has many pharmacological effects,such as anti-depression,anti-inflammation,analgesia,anti-tumor,liver protection,nerve protection,sedation and hypnosis,immunomodulation and so on.It has little toxic and side effects and has been highly concerned by people.At present,paeoniflorin is rarely used in clinical practice in the form of monomers.This article mainly refers to the related research literatures on paeoniflorin pharmacological action in recent three years,combs and summarizes the new progress of its pharmacological action research.The relationship between the drug effect and the prescription of traditional Chinese medicine was discussed,in order to provide a reference for further development and clinical application of paeoniflorin.

关 键 词：芍药苷 芍药 牡丹 抗抑郁 抗炎 镇痛 抗肿瘤 调节免疫 机体保护作用 

分 类 号：R285[医药卫生—中药学]