supported by the Beijing Municipal Government grant(Beijing Laboratory of Oral Health,PXM2021-014226000041);the Beijing Municipal Science and Technology Commission(Z181100001718208);the Beijing Municipal Education Commission(119207020201);the Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201);the Chinese Research Unit of Tooth Development and Regeneration,Academy of Medical Sciences(2019-12M-5031);the National Natural Science Foundation of China(92049201,82030031,81991504,and 92149301);the Beijing Advanced Innovation Center for Big Data-based Precision Medicine(PXM2021_014226_000026);the Beijing Municipal Government(Beijing Scholar Program,PXM2020_014226_000005 and PXM2021_014226_000020);the Beijing Municipal Colleges and Universities High Level Talents Introduction and Cultivate Project-Beijing Great Wall Scholar Program(CIT&TCD 20180332);the National Key Research and development Program(2022YFA1104401)。