血浆置换治疗急性格林巴利综合征疗效的影响因素分析  

The influence factors on the effect of plasma exchange in the treatment of patients with acute GuillainBarré syndrome

作　　者：黄振华 孔德燕[3] 周红卫[1] HUANG Zhen-hua;KONG De-yan;ZHOU Hong-wei(Department of Blood Purification,The First Affiliated Hospital of Guangxi Medical University,Guangxi,Nanning 530021,China;Department of Blood Purification,National Hospital of Guangxi Zhuang Autonomous Region,Guangxi,Nanning 530001,China;Department of Neurology,The Second Affiliated Hospital of Guangxi Medical University,Guangxi,Nanning 530007,China)

机构地区：[1]广西医科大学第一附属医院血液净化科,南宁530021 [2]广西壮族自治区民族医院血液净化科,南宁530001 [3]广西医科大学第二附属医院神经内科,南宁530007

出　　处：《中国血液净化》2019年第1期26-29,共4页Chinese Journal of Blood Purification

基　　金：广西科学研究与技术开发计划项目[桂科攻(14124004-1-3)]

摘　　要：目的探讨血浆置换(plasma exchange,PE)治疗急性格林巴利综合征(Green-Barré syndrome,GBS)疗效的影响因素。方法 118例急性GBS患者分为PE治疗组和未行PE治疗组。比较2组疗效的差异并分析影响PE治疗效果的因素。结果 PE治疗组急性GBS总有效率(73.5%)高于未行PE治疗组(54%),2组总有效率比较差异有统计学意义(P=0.023)。Logistic回归分析发现PE次数(OR2.123 95%CI:1.168～5.321,P=0.019)和轴索损害(OR 4.758 95%CI:1.475～15.350,P=0.009)是影响PE治疗急性GBS疗效的独立影响因素。结论 PE是治疗急性GBS的一种有效的方法,而PE次数和轴索损害可能是PE治疗急性GBS疗效的独立影响因素,这有待进一步的研究证实。Objective To analyze the influence factors on the effect of plasma exchange(PE) in the treatment of patients with acute Guillain-Barré syndrome(GBS). Methods A total of 118 acute GBS patients were divided into PE group and non-PE group. Therapeutic effect was compared between the two groups and the influence factors affecting the PE effect were investigated. Results Fifty GBS patients in PE group were responsive to PE with the effective rate of 73.5%, while 27 GBS patients in non-PE group were responsive with the effective rate of 54%(P=0.023). Multivariate analyses revealed that the number of PE(odds ratio 2.123) and axonal damage(odds ratio 4.758) were the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Conclusion PE is an effective treatment for acute GBS. The number of PE and the axonal damage are the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Further study is required to validate the findings of this study.

关 键 词：格林巴利综合征 血浆置换 疗效 影响因素 

分 类 号：R745.43[医药卫生—神经病学与精神病学] R459.5[医药卫生—临床医学]