抑郁症动物模型及评价方法研究进展  

Research progress on animal models of depression and their evaluation methods

作　　者：薛涛[1] 邬丽莎[1] 刘新民[2] 王琼[1] 

机构地区：[1]泸州医学院,四川泸州646000 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中国实验动物学报》2015年第3期321-326,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：全军医药卫生"十二五"科研项目(BWS11J052);人因工程重点实验室开放基金资助项目(HF2012-K-06);四川省科技厅-泸州市人民政府-泸州医学院联合科研资金项目[14JC01323-LH50]

摘　　要：抑郁症(depression)是一种严重危害人类身心健康的全球性的主要精神卫生问题。目前病因及病理机制尚不完全清楚,但随着社会经济的发展,生活节奏加快,人们的压力增加,情感冲击加大,造成抑郁症发病率逐年增长。随着对抑郁症研究的深入,抑郁症动物模型及其评价方法被广泛运用于抑郁症发病机制研究和抗抑郁新药的研发。动物模型模拟人类疾病状态的程度以及评价方法的可靠性和准确性直接影响实验研究结果的价值。本综述主要介绍了常用的抑郁症动物模型,及整体、器官、分子水平的评价指标,为后续新型抗抑郁药物的研发提供文献参考。Depression,a seriously harmful disease to peoples’ physical and mental health,is prevailing worldwide. But the etiology and pathological mechanism is still not fully uncovered. With the development of social economy and the pace of life speeding up,increasing pressure and vulnerable emotion cause depression incidence increased rapidly. For the further research on depression,study of depression mechanism and antidepressant drugs highly depends on effective animal models. The degree of similarity of animal models to human disease status and the accuracy and reliability of evaluation methods of animal models directly influence the value of the resuts of experiments. In this article we introduce the commonly used animal models of depression,the evaluation indicators at organism,organ,and molecular levels,and to provide theoretical references for the further studies on depression.

关 键 词：抑郁症 动物模型 行为学 生化指标 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R[医药卫生—临床医学]