高原慢性低氧对土生牦牛与迁饲黄牛肾功能影响的比较  

Comparative study of high altitude chronic hypoxia on renal function in yak and migrated cattle on Qinghai-Tibetan plateau

作　　者：李愈娴 刘凤云[1] 胡琳[1] 刘世明[1] 吴天一[1] 

机构地区：[1]科技部省部共建高原医学国家重点实验室青海高原医学科学研究院,西宁810012

出　　处：《中国应用生理学杂志》2016年第5期440-443,共4页Chinese Journal of Applied Physiology

基　　金：科技部973前期资助项目(2012CB722506);科技部973资助项目(2012CB518202)

摘　　要：目的:探讨长期慢性高原暴露对高原土生牦牛(yak)、高山迁饲黄牛(migrated cattle)和低海拔黄牛(lowland cattle)肾功能的影响,探究牦牛和高山迁饲黄牛适应和习服高原的不同特征及差异。方法:采集青海不同地区的牦牛血样,按海拔高度分为3 000 m,3 500 m,4 000 m和4 300 m四个组(n=84),同时采集高山迁饲黄牛(n=22)及低海拔黄牛(n=39)血液,利用全自动血液生化分析仪测定尿素氮(BUN)、肌酐(Cr)、尿素氮/肌酐(BUN/Cr)、尿酸(UA)、二氧化碳结合率(CO_2cp)、葡萄糖(GLU)水平,分析不同海拔高度的牦牛之间及牦牛、高山迁饲黄牛和低海拔黄牛之间的差异。结果:随着海拔的升高,土生牦牛UA、CO_2cp两项升高较显著,与黄牛相比,BUN、BUN/Cr显著高于高山迁饲黄牛和低海拔黄牛,CO_2cp、GLU显著低于低海拔黄牛。低海拔黄牛和高山迁饲黄牛相比,BUN、BUN/Cr显著低于高山迁饲黄牛,UA、CO_2cp显著高于高山迁饲黄牛。结论:土生牦牛对于高原低氧环境有很强的适应能力;高山迁饲黄牛表现出对低氧的不适应性,处于对低氧的应激状态。Objective: To investigate the difference of renal function among yak,migrated cattle on Qinghai-tibetan plateau and lowland cattle,and to further explore the characteristics of renal to adapt chronic hypoxia. Methods: The serum samples of yak( n =84) were collected at 3 000 m,3 500 m,4 000 m and 4 300 m respectively,meanwhile the serum samples of migrated cattle on plateau( n = 22) and lowland cattle( n = 39) were also collected. The levels of blood urea nitrogen( BUN),creatinine( Crea),blood urea nitrogen / creatinine( BUN / Cr),uric acid( UA),carbon dioxide binding rate( CO_2cp),glucose( GLU) in serum were measured by using fully automatic blood biochemical analyzer. We analysed the differences among the above renal functions. Results: With the altitude increased,the results showed the levels of UA and CO_2 cp of yak were increased significantly,as compared to cattle,the levels of BUN and BUN / Cr were increased significantly compared with migrated cattle on plateau and lowland cattle,the levels of CO_2 cp and GLU were decreased significantly compared with lowland cattle. As compared to migrated cattle on plateau,the levels of BUN and BUN / Cr of lowland cattle were decreased significantly,the levels of UA and CO_2 cp were increased significantly. Conclusion: The results indicated that the yak were adapted to the plateau hypoxia environment and migrated cattle maybe not adapt to the low oxygen environment,they were under the stress situation.

关 键 词：慢性低氧 牦牛 黄牛 肾功能 

分 类 号：S823[农业科学—畜牧学]