醋酸确炎舒松-A局部注射治疗小儿口腔颌面血管瘤的效果  

Efficacy of local injection of triamcinolone acetate-A in the treatment of oral and maxillofacial hemangioma in children

作　　者：叶宇[1] 覃毅 覃潇斌 YE Yu;TAN Yi;TAN Xiao-bin(Department of Stomatology,Hospital of Maternal And Child Health Care,Guangxi Zhuang Autonomous Region,Nanning 530003,China)

机构地区：[1]广西壮族自治区妇幼保健院口腔科,南宁530003

出　　处：《中国肿瘤临床与康复》2019年第9期1100-1103,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨醋酸确炎舒松-A局部注射治疗小儿口腔颌面血管瘤的效果。方法选取2017年1月至2018年12月间广西壮族自治区妇幼保健院收治的60例口腔颌面血管瘤患儿作为研究对象,采用随机数表法分为观察组与对照组,每组30例,观察组患者采用醋酸确炎舒松-A局部注射联合常规治疗,对照组患者采用常规治疗,对两组患者治疗前后的血管内皮细胞、生活质量、不良反应发生情况以及临床治疗效果进行综合评价并进行比较。结果两组患者治疗前各项血管内皮细胞相关指标比较,差异无统计学意义(P> 0. 05);治疗后,两组血管内皮细胞相关指标均有所改善,但观察组患儿改善幅度更大,差异均有统计学意义(均P <0. 05)。两组患者治疗前生活质量评分比较,差异无统计学意义(P> 0. 05)。两组患者治疗后生活质量评分显著改善,且观察组优于对照组,差异均有统计学意义(P <0. 05)。观察组有1例患儿出现皮肤溃疡,1例出现腹部不适,不良反应率为6. 7%(2/30),低于对照组的23. 3%,差异有统计学意义(P <0. 05)。观察组患者的治疗总有效率为93. 3%,显著高于对照组患者的70. 0%,差异有统计学意义(P <0. 05)。结论醋酸确炎舒松-A局部注射治疗口腔颌面血管瘤患儿,能促进患儿血管内皮生长因子指标改善,提高生活质量,且不良反应少,值得推广应用。Objective To explore the efficacy of local injection of triamcinolone acetate-A in the treatment of oral and maxillofacial hemangioma in children.Methods Sixty children with oral and maxillofacial hemangioma treated at Hospital of Maternal And Child Health Care from January 2017 to December2018 were divided into an observation group and a control group by random number table method.Each group had 30 patients.The observation group was given local injection of triamcinolone acetate-A combined routine treatment and the control group routine treatment.Vascular endothelial cells,quality of life,incidence of adverse reactions before and after treatment were compared between the two groups.The clinical treatment efficacy was evaluated comprehensively.Results There was no significant difference in indexes associated with vascular endothelial cells between the two groups before the treatment(P>0.05).After the treatment,indexes associated with vascular endothelial cells were improved in both groups with the improvement higher in the observation group than in the control group(all P<0.05).There was no significant difference in quality of life between the two groups before the treatment(P>0.05).After the treatment,quality of life was improved in both groups(P<0.05).The quality of life was better in the observation group than in the control group(P<0.05).Skin ulcer occurred in 1 patient and abdominal discomfort occurred 1 patient.The incidence of adverse reaction was 6.7%(2/30)in the observation group which was significantly lower than 23.3%(7/30)of the control group(P<0.05)..The overall efficacy rate was93.3%in observation group which was higher than 70.0%of the control group(P<0.05).Conclusion Local injection of triamcinolone acetate-A in the treatment of pediatric oral and maxillofacial hemangioma can promote the indexes of vascular endothelial cells and quality of life of patients with few adverse reactions,which is worthy of popularization and application.

关 键 词：醋酸确炎舒松-A 口腔颌面血管瘤 不良反应 生活质量 

分 类 号：R739.81[医药卫生—肿瘤]