术前新辅助化疗结合肠内营养对胃癌患者肿瘤细胞增殖活性的影响分析  

Effect analysis of preoperative neoadjuvant chemotherapy combined with enteral nutrition to tumor cell proliferative activity for gastric cancer patients

作　　者：裴进田 卢芸 阴炳侠 

机构地区：[1]河北省唐山市乐亭县中医医院外科,063600

出　　处：《中华普通外科学文献（电子版）》2015年第6期463-466,共4页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：目的探讨术前新辅助化疗结合肠内营养对胃癌患者肿瘤细胞增殖活性的影响效果。方法将2012年7月至2014年7月收治的132例进展期胃癌患者,随机分为观察组(术前新辅助化疗联合肠内营养)和对照组(单纯予以新辅助化疗),各66例,采用流式细胞仪检测两组患者肿瘤标本的细胞增殖情况,通过CD4、CD8、CD4/CD8、NK细胞的检测评价两组患者的免疫功能,检测血清学指标以及营养风险筛查(NRS评分)进行营养评价。结果治疗前,两组患者的肿瘤细胞增殖活性、免疫指标、营养状况均差异无统计学意义。治疗后,观察组患者的CD4、CD4/CD8、NK、总蛋白、白蛋白、前白蛋白、转铁蛋白、血红蛋白均较对照组增加明显,DI、SPF、PI、CD8、NRS评分降低明显,差异有统计学意义(P<0.05)。结论术前新辅助化疗结合肠内营养可较好地降低肿瘤细胞的增殖活性,改善其免疫水平及营养状况。Objective To discuss the effect of preoperative neoadjuvant chemotherapy combined with enteral nutrition for gastric cancer patients tumor cell proliferative activity. Methods One hundred and thirty-two gastric cancer patients in progressive stage were selected and divided randomly into observation group(preoperative neoadjuvant chemotherapy combined with enteral nutrition), and control group(simply preoperative neoadjuvant chemotherapy). All patients were recorded for and compared in tumor cell proliferative activity, immunity level and nutrition improvement before and after therapy.Results Before therapy, there was no difference between two group in tumor cell proliferative activity,immunity index, and nutriture. After therapy, compared with control group, CD4, CD4/CD8, NK, total protein, albumin, prealbumin, transferring, and hemoglobin all obviously increased in observation group,while DI, SPF, PI, CD8, NRS scores obviously decreased; the differences had statistical significance(P<0.05). Conclusion Preoperative neoadjuvant chemotherapy combined with enteral nutrition can decrease tumor cell proliferative activity in gastric cancer patients, and improve their immunity level and nutrition.

关 键 词：胃癌 进展期 新辅助化疗 肠道营养 细胞增殖活性 免疫水平 营养 

分 类 号：R735.2[医药卫生—肿瘤]