人乳头瘤病毒感染型别对妇女妊娠结局的影响  

Influence of human papillomavirus infection on pregnancy outcomes

作　　者：马丹 宋淑荣[1] 李嘉[1] 梁茜[1] 史艺[1] MA Dan;SONG Shu-rong;LI Jia;LIANG Qian;SHI Yi(Tianjin Third Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院产科,天津300170

出　　处：《中华医院感染学杂志》2019年第5期753-755,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨人乳头瘤病毒(HPV)感染型别对妇女妊娠结局影响。方法回顾性分析2016年1月-2017年1月324例在医院接受产前检查并分娩的人乳头瘤病毒产妇为观察组,选取同期237例在医院接受产前检查并分娩的无人乳头瘤病毒产妇为对照组,统计观察组产妇及观察组新生儿人乳头瘤病毒感染型,对比两组产妇母婴结局。结果观察组新生儿共计发生HPV感染160例(49.38%),产妇与新生儿感染型无直接相关性;观察组产妇早产28例(8.64%)、胎膜早破41例(12.65%)、胎儿生长受限11例(3.40%),对照组孕妇分别为早产11例(4.64%)、21例(8.86%)、3例(1.27%),差异具有统计学意义(P<0.05)。结论产妇HPV感染型主要为高危型,可经垂直传播途径造成宫内感染和新生儿HPV感染,二者感染型无直接相关性,HPV感染与不良母婴结局具有一定相关性,因此妇女有必要孕期进行HPV检测。OBJECTIVE To explore the influence of human papillomavirus(HPV)infection on pregnancy outcomes.METHODS From Jan 2016 to Jan 2017,totally 324 HPV-positive puerpera who received prenatal examination and gave birth in the hospital were chosen as the observation group,meanwhile,237 HPV-negative puerpera who received prenatal examination and gave birth were set as the control group.The genotypes of HPV causing infection were observed and compared between the puerpera and neonates in the observation group,and the maternal and infant outcomes were compared between the two groups.RESULTS Totally 160 neonates(49.38%)had HPV infection in the observation group,and there was no direct correlation between the genotype of HPV in the puerpera and the genotype of HPV in the neonates.There were 28(8.64%)puerpera with premature delivery,41(12.65%)with premature rupture of fetal membrane and 11(3.40%)with fetal growth restriction in the observation group,while the there were 11(4.64%)puerpera with premature delivery,21(8.86%)with premature rupture of fetal membrane and 3(1.27%)%with fetal growth restriction in the control group,the differencs significant(P<0.05).CONCLUSIONThe high-risk genotype of HPV is dominant among the HPV causing the infection in the puerpera,which may lead to the intrauterine infection and neonatal HPV infection through vertical transmission,and there is no direct correlation between the two,the HPV infection shows certain correlation with the adverse maternal and infant outcomes,and it is necessary for pregnant women to take HPV test.

关 键 词：人乳头瘤病毒 感染型 妇女 妊娠 

分 类 号：R737.33[医药卫生—肿瘤]