体重指数与结直肠癌预后的相关性研究  

Association between body mass index and prognosis of colorectal cancer

作　　者：邹振玉[1] 宁宁[1] 刘海亮[2] 李松岩[1] 杜晓辉[1] 李荣[1] 

机构地区：[1]解放军总医院普通外科,北京100853 [2]解放军总医院肿瘤外科,北京100853

出　　处：《中华结直肠疾病电子杂志》2015年第3期289-295,共7页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金(61170123);海南省自然科学基金(813226)

摘　　要：目的探讨体重指数(body mass index,BMI)与结直肠癌患者临床病理特征和预后的关系。方法回顾性分析2005年7月至2011年6月解放军总医院收治的107例结直肠癌患者的临床和随访资料。将患者分为正常体重组(BMI<23.0kg/m2)、超重组(23.0 kg/m2≤BMI<27.5 kg/m2)和肥胖组(BMI≥27.5 kg/m2),比较三组临床病理因素,并分析BMI与5年生存率的关系。结果正常体重组37例(34.6%),超重组54例(50.5%),肥胖组16例(14.9%)。中位生存时间为37个月,1、3、5年的总生存率分别为95.3%、81.9%、74.0%。单因素生存分析显示,肿瘤位置、浸润程度、淋巴结转移和临床分期对5年生存率有影响(均P<0.05)。BMI与肿瘤浸润程度有关(P=0.039),对5年生存率无显著影响,但随着BMI增加,5年生存率呈上升趋势(69.2%vs 72.0%vs93.8%,P=0.239)。多因素生存分析显示,肿瘤位置和临床分期是本组患者预后的独立危险因素(均P<0.05),BMI非独立危险因素(P=0.343)。结论 BMI对结直肠癌患者的预后无显著影响。Objective To explore the association between body mass index ( BMI ) , clinicopathological characteristics, and prognosis of colorectal cancer patients.Methods Medical records and follow-up data of 107 patients with colorectal cancertreated in Chinese PLA General Hospital from July 2005 to June 2011 were analyzed retrospectively.The patients were divided into normal weight group( BMI<23.0kg/m2),overweight group(23.0 kg/m2≤BMI<27.5 kg/m2),and obese group(BMI≥27.5 kg/m2). The clinicopathological factors were compared among these three groups and the association between BMI and 5-year overall survival rate was analyzed.Results There were 37 patients(34.6%) in the normal weight group,54 patients(50.5%)in the overweight group,and 16 patients(14.9%)in the obese group.The median survival time was 37 months.The 1-,3-and 5-year overall survival rates were 95.3%,81.9%,and 74.0%, respectively.According to the Kaplan-Meier method, tumor site, infiltrating degree, lymph metastasis, and clinical stage had significant effects on 5-year overall survival rate ( P <0.05, respectively).BMI was significantly relevant to tumor infiltrating degree(P=0.039).No statistically significant correlation was found between BMI and 5-year overall survival rate,but the elevated BMI showed a trend toward increased 5-year overall survival rate(69.2% vs 72.0% vs 93.8%,P=0.239).Cox proportional hazards model indicated that the tumor site and clinical stage were significant independent risk factors(P<0.05,respectively),but BMI was not(P=0.343).Conclusions There is no significant association between BMI and prognosis of patients with colorectal cancer.

关 键 词：结直肠肿瘤 体重 预后 

分 类 号：R735.34[医药卫生—肿瘤]