结直肠腺癌组织Caveolin-1表达与微淋巴管密度的关系及临床意义  

Correlation of Caveolin-1 expression with microlymphatic density in colorectal adenocarcinoma tissues and its clinical significance

作　　者：郭飞[1] 薛军[1] 武雪亮[1] 宇宏峰 屈明[1] 张鹏程[1] 孙光源 胡晓峰[1] 王立坤[1] 

机构地区：[1]河北北方学院附属第一医院血管腺体外科,河北张家口075000

出　　处：《江苏大学学报（医学版）》2015年第3期225-228,共4页Journal of Jiangsu University：Medicine Edition

基　　金：张家口市科技局2013指令性计划(1311055D)

摘　　要：目的:探索结直肠腺癌中Caveolin-1和微淋巴管密度(lymphatic microvessel density,LMVD)的关系及其与肿瘤临床病理特征和预后的关联。方法:运用免疫组织化学法测定90例结直肠腺癌和45例正常结直肠组织中Caveolin-1的表达,并以D2-40为标记物,测定结直肠腺癌组织的LMVD,分析Caveolin-1和LMVD与临床病理参数之间的关联。结果:结直肠腺癌中Caveolin-1蛋白的阳性表达率(73.33%)明显高于正常结直肠组织(11.11%,P<0.01);结直肠腺癌中的LMVD值(18.25±2.36)明显高于正常结直肠组织(3.14±1.58,P<0.01);Caveolin-1表达程度和LMVD与肝转移、肿瘤浸润深度、淋巴结转移和TNM分期具有相关性(P<0.01);Caveolin-1表达阴性组的LMVD值明显低于阳性组(P<0.01);结论:Caveolin-1在结直肠癌中的表达与微淋巴管生成密切相关,其表达和LMVD是结直肠癌患者的独立预后指标。Objective: To study the expression of Caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic density( LMVD),and to investigate the clinical pathological prognostic significance of Caveolin-1 and LMVD in patients with colorectal cancer. Methods: The expression of Caveolin-1 and LMVD in 45 specimens of normal colorectal tissues,and 90 specimens of colorectal adenocarcinoma tissues were detected by immunohistochemistry technique. We also investigated the correlation between their expression and the clinicopathologic tissues features. Results: The positive rates of Caveolin-1 in colorectal adenocarcinoma( 73. 33%) were significantly higher than those in normal colorectal tissues( 11. 11%,P < 0. 01); The positive rates of LMVD in colorectal adenocarcinoma tissues( 18. 25 ± 2. 36)were significantly higher than those in normal colorectal tissues( 3. 14 ± 1. 58,P < 0. 01). Expression of Caveolin-1 and LMVD value was correlated with liver metastasis,lymph node metastasis,TNM stage and the depth of tumor invasion. The mean LMVD in group with Caveolin-1 positivity expression was significantly higher than in that with Caveolin-1 negativity expression. Conclusion: The expression of Caveolin-1 in colorectal cancer was closely related to lymphatic microvessel of tumor,and its expression and LMVD were independent prognostic indicators for patients with colorectal cancer.

关 键 词：结直肠腺癌 CAVEOLIN-1 微淋巴管密度 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]