泻剂结肠大鼠结肠中的mu、kappa阿片受体变化  

Changes of mu and kappa opioid re- ceptors in cathartic colon of rats

作　　者：刘宝华[1] 莫平 张胜本[1] 

机构地区：[1]中国人民解放军第三军医大学附属大坪医院野战外科研究所普通外科,重庆市400042

出　　处：《世界华人消化杂志》2003年第5期569-570,共2页World Chinese Journal of Digestology

摘　　要：目的:探讨mu、kappa阿片受体在泻剂结肠大鼠结肠中的变化.方法:以泻剂复制大鼠泻剂结肠模型,观察泻剂结肠的mu、kappa阿片受体活性.结果:泻剂结肠的mu阿片受体的最大结合数和解离常数明显高于对照组(207.00±22.9vs82.00±4.23fmol/mg.p,P<0.01;3.30±0.45vs2.40±0.57mmol/L,P<0.05).与对照组相比,泻剂结肠的kappa阿片受体最大结合数明显增高(957.00±102.41vs459.00±52.41fmol/mg.p,P<0.01),解离常数无明显的差异.结论:mu,kappa阿片受体可能参与了泻剂结肠的功能紊乱,mu阿片受体较重要.AIM:To study the changes of mu and kappa opioid receptors in cathartic colon of rats. METHODS:An experimental rat model of cathartic colon was reconstructed by contact laxatives mixed with the feed. The activity of mu, kappa opioid receptors in cathartic colon of rats was determined. RESULTS:The maximal binding capacity (Bmax) and affinity (Kd) of mu opioid receptor in cathartic colon of rats were significantly increased as compared with the control group (207.00±22.9 vs 82.00±14.23 fmol/mg·p, P <0.01; 3.30±0.45 vs 2.40±0.57 mmol/L, P <0.05). As compared with the control group, the maximal binding capacity of kappa opioid receptor was significantly increased (957.00±102.41 vs 459.00±52.41 fmol/mg·p, P <0.01), and no remarkable change of affinity was found in cathartic colon of rats. CONCLUSION:The data indicates that mu and kappa opioid receptors may be involved in the disorder of cathartic colon, but the mu opioid receptor may be more important.

关 键 词：泻剂 大鼠 mu阿片受体 kappa阿片受体 慢传输性便秘 发病机制 

分 类 号：R574.62[医药卫生—消化系统]