Fabrication and characterization of electrospun poly-L-lactide/gelatin graded tubular scaffolds: Toward a new design for performance enhancement in vascular tissue engineering  

作　　者：A.Yazdanpanah M.Tahmasbi G.Amoabediny J.Nourmohammadi F.Moztarzadeh M.Mozafari 

机构地区：[1]Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology [2]School of Mechanical Engineering, Sharif University of Technology [3]Faculty of Chemical Engineering, College of Engineering, University of Tehran [4]Biomaterials Group, Faculty of New Sciences and Technologies, University of Tehran [5]Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC)

出　　处：《Progress in Natural Science:Materials International》2015年第5期405-413,共9页自然科学进展·国际材料（英文版）

摘　　要：In this study, a new design of graded tubular scaffolds have been developed for the performance enhancement in vascular tissue engineering.The graded poly-L-lactide(PLLA) and gelatin fibrous scaffolds produced by electrospining were then characterized. The morphology,degradability, porosity, pore size and mechanical properties of four tubular scaffolds(graded PLLA/gelatin, layered PLLA/gelatin, PLLA and gelatin scaffolds) have been investigated. The tensile tests demonstrated that the mechanical strength and also the estimated burst pressure of the graded scaffolds were significantly increased in comparison with the layered and gelatin scaffolds. This new design, resulting in an increase in the mechanical properties, suggested the widespread use of these scaffolds in vascular tissue engineering in order to prepare more strengthened vessels.In this study, a new design of graded tubular scaffolds have been developed for the performance enhancement in vascular tissue engineering.The graded poly-L-lactide(PLLA) and gelatin fibrous scaffolds produced by electrospining were then characterized. The morphology,degradability, porosity, pore size and mechanical properties of four tubular scaffolds(graded PLLA/gelatin, layered PLLA/gelatin, PLLA and gelatin scaffolds) have been investigated. The tensile tests demonstrated that the mechanical strength and also the estimated burst pressure of the graded scaffolds were significantly increased in comparison with the layered and gelatin scaffolds. This new design, resulting in an increase in the mechanical properties, suggested the widespread use of these scaffolds in vascular tissue engineering in order to prepare more strengthened vessels.

关 键 词：Tubular scaffolds ELECTROSPINNING POLY-L-LACTIDE GELATIN VASCULAR tissue engineering 

分 类 号：R318.1[医药卫生—生物医学工程]