快速动眼睡眠行为障碍症10例报告  

REM sleep behavior disorder:a review of 10 cases

作　　者：宿长军[1] 游国雄[1] 刘煜[1] 竺士秀[1] 杨婷[1] 

机构地区：[1]第四军医大学唐都医院神经科,西安710038

出　　处：《中华神经科杂志》2003年第3期214-216,共3页Chinese Journal of Neurology

摘　　要：目的　介绍快速眼动 (REM )睡眠行为障碍症 (RBD)的临床表现 ,探讨其原因和可能的发病机制。方法　对由多导睡眠图确诊的 10例RBD患者进行回顾性分析。结果　 10例患者发病年龄均为中老年人 ,男性 9例 ,表现睡梦中出现粗暴动作、喊叫和其他行为异常 ,其中 4例为帕金森病患者 ,2例多系统萎缩 ,1例脑外伤 ,3例原因不明 ;睡前服用氯硝安定可控制发作。全部多导睡眠图(PSG)均为REM睡眠期肌弛缓现象消失而伴随肌电活动。结论　对睡眠中出现的异常行为特别是粗暴动作者 ,应考虑本病的可能 ,PSG有助确诊并与癫鉴别 ,氯硝安定治疗有效。Objective To introduce the clinical manifestations of REM sleep behavior disorder (RBD) which hasn't been reported in China ever before and to discuss the possible causes and mechanisms of the disease. Methods Ten cases of RBD verifted by polysomnography(PSG)were analyzed retrospectively. Results All patients were senile or in middle ages and most of them were male.The main clinical features included violent movements,shouting and other abnormal behaviors occuring in dreams when they fell asleep.Four cases were diagnosed as Parkinsonism,2 as multiple system atrophy and 1 as cerebral trauma.The causes of another 3 cases were unknown.all symptoms of them were relieved by using clonazepam administered prior to sleep.The PSG of all cases showed a loss of normal muscular atonia and an appearance of EMG activities during REM sleep. Conclusions RBD should be considered when patients showed abnormal especially violent behaviors in sleep.PSG should be essential for its correct diagnosis and the differentiation from partial complex epilepsy.Clonazepam given prior to sleep should be effective for treatment.

关 键 词：快速动眼睡眠行为障碍症 临床表现 发病机制 多导睡眠图 帕金森病 

分 类 号：R741[医药卫生—神经病学与精神病学]