三阴性乳腺癌的分子分型及应用  

Molecular Classification of Triple Negative Breast Cancer and Its Applications

作　　者：谭莉[1] 周茜[1] 王艺蓁 祖旭宇[1] 

机构地区：[1]南华大学附属第一医院内分,衡阳421001

出　　处：《肿瘤防治研究》2015年第3期300-304,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81272355);湖南省自然科学基金(11JJ4068)

摘　　要：三阴性乳腺癌是指雌激素受体、孕激素受体及人表皮生长因子受体均为阴性表达的一类乳腺癌,它是一类具有独特生物学及临床特征的乳腺癌亚型,具有进展快、复发早及预后差的特点。根据三阴性乳腺癌的分子特性,可将其分为六种基因表达亚型。研究表明三阴性乳腺癌基因表达亚型和特定的基因突变亚型之间存在重要关联,这一发现可能为不同亚型的三阴性乳腺癌的个体化治疗提供重要的治疗靶点。本文将概括目前对于三阴性乳腺癌亚型分类的认识,以及这种分类在将来临床实践中的应用。Triple negative breast cancer(TNBC) is one kind of breast cancer with generally negative expression of estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor(Her-2), moreover, it is also one kind of breast cancer subtypes with uniquely biological and clinical characteristics, and features of early recurrence, quick progressing and poor prognosis. According to the molecular features of TNBC, it could be divided into six kinds of gene expression subtypes. Researches show that there are important connection between specific gene mutation subtypes and gene expression subtypes of TNBC, which might provide important individual therapeutic strategy for different subtypes of TNBC. In this review, we would summarize the current understanding of TNBC subtype classification, and describe how this kind of classification could be applied to clinical practice in the future.

关 键 词：三阴性乳腺癌 基因表达亚型 临床应用 

分 类 号：R737.9[医药卫生—肿瘤]