25-羟基维生素D与结直肠癌关系的Meta分析  

Meta-analysis of Relationship Between Blood 25-hydroxyvitamin D Level and Colorectal Cancer

作　　者：于慧会[1,2] 魏立璇[1] 刘运泳[1,2] 邢晓静[1,2] 

机构地区：[1]辽宁省肿瘤医院.研究所,沈阳110042 [2]辽宁省肿瘤防治办公室,沈阳110042

出　　处：《肿瘤防治研究》2015年第4期394-398,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金项目(181201968);辽宁省科技公关项目(2012225016);辽宁省自然科学基金(201102111)

摘　　要：目的探讨25-羟基维生素D水平与结直肠癌的关系,为结直肠癌的防治和病因探索提供证据。方法检索MEDLINE、EMBASE等大型数据库中2003至2013年发表的有关25-羟基维生素D水平与结直肠癌关系的前瞻性研究文献。采用Meta分析方法,应用Stata11.0软件评价25-羟基维生素D水平与结直肠癌的关系。结果 (1)血液25-羟基维生素D水平最高组与最低组在结直肠癌组与对照组间比较差异有统计学意义(RR=0.79,95%CI:0.65~0.95)。(2)地区亚组分析显示,血液25-羟基维生素D水平最高组与最低组间比较差异均无统计学意义。美洲组RR=0.78(95%CI:0.60~1.02),欧洲组RR=0.77(95%CI:0.56~1.06),亚洲组RR=0.89(95%CI:0.52~1.50)。(3)Egger’s检验法检验无统计学意义(P>0.05),Begg’s漏斗图基本对称,所以没有显著的发表偏倚。结论血液25-羟基维生素D水平与结直肠癌存在联系,补充维生素D对结直肠癌的预防和治疗有一定意义。Objective To investigate the association between blood 25-hydroxyvitamin(OH) D level and colorectal cancer, and to provide evidence for the prevention strategy and understanding of the etiology of colorectal cancer. Methods MEDLINE, EMBASE and other large databases were searched. The prospective studies about the association of 25-(OH) D and colorectal cancer published from 2003 to May 2013 were selected. A comprehensive quantitative analysis was performed by Meta-analysis method with Stata11.0 software. Results Meta-analysis results showed that the pooled RRs of colorectal cancer for the highest versus lowest categories of blood 25-(OH)D levels were 0.79(95%CI:0.65~0.95). Stratifying by geographic region, the pooled RRs of colorectal cancer for the highest versus lowest categories of 25-(OH)D levels for studies conducted in the United States, Europe and Asia were 0.78(95%CI:0.60-1.02),0.77(95%CI:0.56-1.06), 0.89(95%CI:0.52-1.50), respectively. Egger’s test showed that the publication bias had no statistical significance(P>0.05). Begg’s funnel plot was symmetric figure, so there was no significant publication bias. Conclusion Blood 25-(OH)D level is associated with the risk of colorectal cancer. Intake of Vitamin D might be useful for the prevention and treatment of colorectal cancer.

关 键 词：25-羟基维生素D 维生素D 结直肠癌 META分析 

分 类 号：R735.34[医药卫生—肿瘤]