放射性核素标记Exendin-4类似物用于胰岛素瘤显像的研究进展  

Recent Advances in Radionuclide-labeled Analogues of Exendin-4 for Insulinoma Imaging

作　　者：许清[1] 杨敏[2] 罗世能[1,2] 

机构地区：[1]南京医科大学第一附属医院放疗科,南京210029 [2]江苏省原子医学研究所,无锡214063

出　　处：《肿瘤防治研究》2015年第4期407-411,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81101077);江苏省自然科学基金(BK2011166);江苏省卫生厅面上项目(H201028);江苏省医学重点人才培养项目(RC2011095);江苏省科技支撑计划(BE2012622);江苏省临床医学科技专项项目(BL2012031)

摘　　要：胰岛素瘤是常见的胰腺内分泌肿瘤,常规方法难以检测。核素显像如单光子断层扫描(SPECT)和正电子断层扫描(PET)具有无创、敏感度高、特异性好等优势,为胰岛素瘤的诊断提供了新技术。胰高血糖素样肽-1受体(GLP-1R)在胰岛素瘤中高表达,是潜在的肿瘤靶点。Exendin-4作为GLP-1R激动剂,可与受体特异性结合。本文介绍放射性核素标记GLP-1R激动剂(Exendin-4)类似物的进展及在胰岛素瘤显像研究中的应用。Insulinoma is one of the most common pancreatic endocrine neoplasm and is difficult to be detected by typical technology. Radionuclide imaging methods such as SPECT and PET have provided a new technology for insulinoma diagnosis with advantages of non-invasive, high sensitivity and specificity. Glucagon-like peptide-1 receptor(GLP-1R) is an attractive target for imaging due to its overexpression in insulinoma. Exendin-4, the agonist of GLP-1R, could specifically bind to the receptor. This paper reviews the progress of radionuclide-labeled Exendin-4 analogs in insulinoma imaging.

关 键 词：放射性核素 胰高血糖素样肽-1受体 EXENDIN-4 放射性核素显像 

分 类 号：R736.7[医药卫生—肿瘤] R730.44[医药卫生—临床医学]