甘肃省105例脑胶质瘤治疗情况回顾性分析  

Retrospective Analysis of Treatment Situation in Gansu Province:105 Cases of Glioma

作　　者：牛小东[1] 张祎年[2] 冉俊涛[3] 王振伟[4] 朱琳[1] 陈宝余 薛敏[1] 焦聚阳 潘亚文[2] 

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]兰州大学第二医院神经外科,兰州730030 [3]甘肃省肿瘤医院放疗科,兰州730050 [4]兰州大学第一临床医学院,兰州730000

出　　处：《肿瘤防治研究》2015年第6期568-570,共3页Cancer Research on Prevention and Treatment

基　　金：高等学校博士学科点专项科研基金(2013021 1120026);甘肃省卫生行业科研计划管理项目(GWGL 2013-31);兰州市科技计划项目(2014-01-30)

摘　　要：目的了解甘肃省内脑胶质瘤治疗情况,并与当前所用诊断和治疗指南对比,分析存在的差异。方法收集2011年1月至2014年1月在兰州大学第二医院和甘肃省肿瘤医院治疗的脑胶质瘤患者临床资料,分析胶质瘤患者的年龄、性别、部位的分布特征及手术、放化疗方案等治疗情况。结果共收集脑胶质瘤病例105例,治疗方案均为手术和放化疗,化疗方案有TMZ和VP方案。其中59.0%(62/105)的患者接受化疗,69例高级别胶质瘤(HGG)患者中,有72.6%(45/69)的患者接受了化疗,而接受化疗的HGG患者中仅有40.0%(18/45)采用TMZ方案,60.0%(27/45)的患者采用VP方案(χ2=2.583,P<0.05),而指南中强烈推荐术后应行辅助放化疗。结论当前甘肃省内胶质瘤在化疗方案上与指南中推荐差异甚大,建议临床医生在我国指南的指导下,应尽可能做到"个体化治疗,规范化实施"。Objective To learn about the current treatments on glioma patients in Gansu Province,and to compare the differences between current treatments and China Clinical Practice Guidelines for the diagnosis and treatment of central nervous system glioma.Methods We collected the clinical data of 105 glioma patients treated in the Lanzhou University Second Hospital and Gansu Province Tumor Hospital from Jan.2011 to Jan.2014.Age,gender,tumor location,surgery and chemoradiotherapy were fully analyzed.Results Totally 105 glioma patients were included,68 males and 37 females.Main treatment methods on all glioma patients included surgery and chemoradiotherapy.The chemotherapy regimens were VP and TMZ.59.0%(62/105) of glioma patients received chemotherapy.Within 69 patients with high-grade glioma,72.6%(45/69) of patients received chemotherapy,among which 40.0%(18/45) received TMZ regimen and 60.0%(27/45) received VP regimen(χ2=2.583,P<0.05).Whereas,China Clinical Practice Guidelines for glioma strongly recommends postoperative adjuvant chemoradiotherapy.Conclusion Comparing current treatments in Gansu Province with China Clinical Practice Guidelines for glioma,there are obvious difference in treatment aspects,especially in chemotherapy.Under the guide of glioma guidelines,clinical doctors should establish a feasible individualized comprehensive treatment,which is 'individualized treatment,standardization implementation'.

关 键 词：脑胶质瘤 替莫唑胺 治疗 回顾性分析 

分 类 号：R739.4[医药卫生—肿瘤]