黑色素瘤相关抗原-A:食管癌免疫治疗新靶点  

MAGE-A:New Target of Immunotherapy for Esophageal Cancer

作　　者：刘维华[1,2] 桑梅香[1,3] 单保恩[1,3] 

机构地区：[1]河北医科大学第四医院科研中心,石家庄050011 [2]石家庄市疾病预防控制中心,石家庄050011 [3]河北医科大学第四医院肿瘤研究所,石家庄050011

出　　处：《肿瘤防治研究》2015年第6期622-626,共5页Cancer Research on Prevention and Treatment

基　　金：河北省自然科学基金(H2012206077)

摘　　要：黑色素瘤相关抗原(melanoma-associated antigen,MAGE)-A亚家族是MAGE基因家族成员,属于癌睾丸抗原,包括MAGE-A1~MAGE-A12,定位于X染色体。MAGE-A在正常组织中几乎不表达,而在多种肿瘤组织中表达,其在食管癌细胞系和食管癌组织均有较高表达。MAGE-A基因编码的抗原肽可由食管癌细胞MHCⅠ分子提呈至细胞毒性T细胞,能够发挥特异性抗肿瘤活性。因此,以MAGE-A抗原为新靶点,对食管癌患者进行免疫治疗有良好的前景。Melanoma-associated antigens-A(MAGE-A) are the subfamily of MAGE genes,locate in the human X chromosome and belong to cancer testis antigens(CTA),which are composed of 12 members,MAGE-A1-MAGE-A12.MAGE-A are rarely expressed in normal tissues,but frequently expressed in a variety of tumor tissues,especially highly expressed in esophageal cancer tissues and esophageal carcinoma cell lines.In addition,the peptides encoded by MAGE-A can be presented to cytotoxic T cells(CTL) by MHCⅠ molecules in esophageal cancer cells,which plays an important role in anti-tumor activity in a specific manner.Therefore,MAGE-A antigens are of great potential as a new target of immunotherapy in the treatment for esophageal cancer in the future.

关 键 词：黑色素瘤相关抗原-A 食管癌 癌睾丸抗原 免疫治疗 

分 类 号：R735.1[医药卫生—肿瘤]