肿瘤长度、最大横径和体积对临床N0期食管鳞癌患者预后的影响  

Effect of Tumor Length,Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients

作　　者：高红梅[1] 肖国伟[1] 池书平[1] 沈文斌[2] 

机构地区：[1]石家庄市第一医院放射科,石家庄050011 [2]河北医科大学第四医院放疗科,石家庄050011

出　　处：《肿瘤防治研究》2015年第8期777-781,共5页Cancer Research on Prevention and Treatment

摘　　要：目的探讨临床无转移食管鳞癌的肿瘤局部因素对患者预后的影响情况。方法回顾性分析符合入组条件的263例N0期食管鳞癌患者,对患者的食管钡餐造影病变长度、GTV最大横径、GTV长度及GTV体积等肿瘤局部因素对患者预后的影响情况进行分析。结果 ROC曲线分析结果显示食管钡餐造影病变长度、GTV最大横径、GTV长度及GTV体积预测患者预后的临界值分别为4.25、1.80、5.85 cm和27.98 cm3。单因素分析结果显示:食管钡餐造影病变长度(P=0.0004)、GTV最大横径(P=0.0246)、GTV长度(P=0.0035)及GTV体积(P=0.0184)均为患者生存率的预后影响因素;食管钡餐造影病变长度(P=0.0149)为患者局部控制率的影响因素。多因素分析结果显示:食管钡餐造影病变长度(P=0.0013)、GTV最大横径(P=0.0047)及GTV长度(P=0.0032)为患者生存率的独立性预后影响因素;食管钡餐造影病变长度(P=0.0037)为患者局部控制率的独立性预后影响因素。结论食管钡餐造影病变长度为临床无转移食管癌主要预后影响因素,在临床上应对食管钡餐造影病变较长的患者给予足够的重视,并予以积极治疗。Objective To investigate the effect of tumor local factors on the prognosis of non-metastasis esophageal squamous cell carcinoma(ESCC) patients. Methods We retrospectively analyzed the clinical data of 263 ESCC patients. The effects of barium meal length, GTV maximum diameter, GTV length and GTV volume on the prognosis of patients were analyzed. Results ROC curve analysis showed that the prognosis critical value of barium meal length, GTV maximum diameter, GTV length and GTV volume were 4.25, 1.80, 5.85 cm and 27.98 cm3, respectively. Univariate analysis showed that barium meal length(P= 0.0004), GTV maximum diameter(P=0.0246), GTV length(P=0.0035) and GTV volume(P=0.0184) were the prognostic factors for survival rate; the barium meal length(P=0.0149) was the prognostic factor for local control rate. Multivariate analysis showed that barium meal length(P=0.0013), GTV maximum diameter(P=0.0047) and GTV length(P=0.0032) were the independent prognostic factors for survival rate; the barium me al length(P=0.0037) was the independent prognostic factor for local control rate. Conclusion The ba-rium meal length is the main prognosis factor for non-metastasis ESCC patients, so we suggest that the clinical physician must give enough attention and active treatment to the patients with long barium meal.

关 键 词：食管癌 放射治疗 临床无转移 肿瘤局部因素 预后 

分 类 号：R735.1[医药卫生—肿瘤]