电针对单纯性肥胖大鼠脂肪组织CRP、IL-6表达的影响  

Influence of electroacupuncture on CRP and IL-6 expressions in adipose tissue of simple obesity rat

作　　者：尹刚[1] 申国明[1] 方正清[1] 许冠荪[1] 王浩[1] 戴婷婷[1] 

机构地区：[1]安徽中医药大学,安徽合肥230038

出　　处：《中国老年学杂志》2015年第6期1623-1624,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金(No.81072871);安徽中医药大学自然科学基金(No.2012qn008)

摘　　要：目的探讨电针对单纯性肥胖大鼠脂肪组织C-反应蛋白(CRP)、白细胞介素(IL)-6表达的影响。方法采用高脂饲料喂养大鼠制造肥胖模型60只,按照随机数字表法将肥胖大鼠分为试验组和对照组,每组30只,对照组不给予电针刺激,试验组给予足三里和三阴交电针针刺,连续治疗半个月。计算治疗前后两组的Lee指数,并测量两组血胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL),并测量脂肪组织中的CRP和IL-6基因mRNA的表达水平。结果治疗后试验组Lee指数显著下降(P<0.05),与对照组比较差异具有统计学意义(P<0.05);试验组TC、TG、HDL和LDL水平显著低于对照组(P<0.05);试验组CRP和IL-6 mRNA的表达水平显著低于对照组(P<0.05)。结论电针能改善肥胖大鼠脂肪组织CPR和IL-6的基因表达,改善其炎症状态。Objective To study the influence of electroacupuncture on CRP and IL-6 expressions in adipose tissue of simple obesity rat. Methods 60 obesity models rats were randomly divided into trial and control groups,30 rats in each group. Control group was not treated with electroacupuncture stimulation,while the trial group was treated with electroacupuncture stimulation on zusanli and sanyinjiao,continued for half a month. Lee’s index before and after the treatment,and TC,TG,LDL,HDL,and the gene mRNA expressions of CRP and IL-6 in adipose tissue were also tested between two groups. Results Lee’s index of trial group was significantly dropped after treatment,which was statistically different from before the treatment( P < 0. 05),and that of control group( P < 0. 05); The levels of TC,TG,HDL and LDL in trial group were significantly lower than those of control group( P < 0. 05); the level of CRP and IL-6 mRNA in trial group were significantly lower than those of control group( P < 0. 05). Conclusions Electroacupuncture could improve the gene expressions of CRP and IL-6 in simple obesity rat adipose tissue,and ameliorate its inflammation state.

关 键 词：C-反应蛋白 白细胞介素6 电针 肥胖 

分 类 号：R245[医药卫生—针灸推拿学]