精神分裂症患者攻击行为与肌酸激酶、肌酸激酶同工酶及性激素水平的相关性分析  

Relationships among aggression and creatine kinase,creatine kinase isoenzyme,sex hormone levels in schizophrenic patients

作　　者：薛坤喜 万静 胡玲玲 李庆伟 黄彩英 

机构地区：[1]中山市第三人民医院早期干预科,广东省528451

出　　处：《中华临床医师杂志（电子版）》2017年第10期1776-1781,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：中山市卫生局医学科研立项课题(2013A020189)

摘　　要：目的探讨血清肌酸激酶(CK)、肌酸激酶同工酶(CKMB)及雌二醇(E2)、催乳素(PRL)、睾酮(T)等性激素水平与精神分裂症患者攻击行为的相关性。方法以2014年5月至2016年5月在早期干预科住院的精神分裂症患者为研究对象,所有患者均处于急性发作期。依据既往暴力史和修订版外显攻击行为量表(MOAS)加权总分分为攻击组(n=99)和非攻击组(n=65)。比较两组患者入组前及治疗后第14、28天阳性与阴性症状量表(PANSS)总分、血清CK、CKMB、E2、PRL、T水平,并对入组前MOAS加权总分、分量表评分与PANSS总分、分量表评分及CK、CKMB、E2、PRL、T水平之间作相关分析。两组计量资料比较采用独立样本t检验,计数资料比较采用?2检验,入组前及治疗后第14、28天数据比较采用重复测量数据的方差分析,采用Pearson检验进行相关性分析。结果攻击组MOAS加权总分、言语攻击、对财产的攻击、自身攻击、体力攻击的评分[(12.33±5.22)分、(2.13±2.23)分、(2.75±2.60)分、(1.73±3.48)分、(5.94±4.76)分]均高于非攻击组[(1.42±1.22)分、(1.16±1.12)分、(0.13±0.49)分、(0.14±0.64)分、(0.00±0.00)分],差异均有统计学意义(P<0.01)。攻击组患者入组前PANSS总分、阳性症状评分、一般精神病理评分[(90.13±13.49)分、(24.03±5.19)分、(48.99±8.59)分]均高于非攻击组[(80.67±11.57)分、(20.30±6.88)分、(42.81±7.47)分],差异均有统计学意义(P<0.05)。治疗后第14、28天两组PANSS总分比较差异无统计学意义(P>0.05)。两组患者在入组前,治疗后第14、28天,CK、CKMB、E2、PRL、T水平的比较差异均无统计学意义(P>0.05)。MOAS加权总分与PANSS总分、阳性症状评分、一般精神病理评分及CK水平存在正相关(r值分别为0.405、0.241、0.531、0.448,P均<0.05)。言语攻击与一般精神病理评分存在正相关(r=0.189,P<0.05)。自身攻击与PANSS总分、一般精神病理评分及CK水平存在正相关(r值分别Objective To explore the relationships among creatinekinase, creatinekinase isoenzyme, estradiol, prolactin, testosterone hormone levels and aggression in schizophrenic patients. Methods These schizophrenic patients were chosen to participate in this study who admitting to the early intervention department from May, 2014 to May, 2016. All the patients were in acute phase. According to the past violence history and modified overt aggression scale(MOAS) scores, patients were divided into aggressive group(n=99) and non-aggressive group(n=65). Positive and Negative Syndrome Scale(PANSS) total scores, creatinekinase, creatinekinase isoenzyme, estradiol, prolactin, testosterone levels were compared between the two groups before and after 14, 28 days treatment. And correlations of PANSS and sub-scales scores, creatinekinase, creatinekinase isoenzyme, estradiol, prolactin, testosterone levels with MOAS weighted total scores and subscales scores were analyzed before these patients receiving treatment. The independent sample t test was used for measurement data and ?2 test was used for count data in both two groups. Before and after 14, 28 days treatment data comparison was used of variance analysis of repeated measurement. Pearson correlative analysis was adopted to analyze the correlations. Results Weighted total scores of MOAS, verbal attack, attack on property, auto-aggression and physical attack scores in aggressive group [(12.33±5.22) scores,(2.13±2.23) scores,(2.75±2.60) scores,(1.73±3.48) scores,(5.94±4.76) scores] were higher than non-aggressive group[(1.42±1.22) scores,(1.16±1.12) scores,(0.13±0.49) scores,(0.14±0.64) scores,(0.00±0.00) scores] and the differences between the two groups were significant(P<0.01). Total scores of PANSS, positive symptoms and general psychopathology scores in aggressive group[(90.13±13.49)scores,(24.03±5.19) scores,(48.99±8.59) scores] were higher than non-aggressive group [(80.67±11.57) scores,(20.30±6.88) scores,(42.81±7.47) scores], and the differences between the

关 键 词：精神分裂症 攻击行为 肌酸激酶 肌酸激酶同工酶 性激素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]