几种新型苯甲酰基脲类几丁质抑制剂的合成(Ⅱ)  

Synthesis of Several Novel Benzoylurea Chitin Inhibitors(Ⅱ)

作　　者：徐蓉[1] 林军[1] 冒德寿[1] 严胜骄[1] 宗乾收[1] 杨丽娟[1] 刘复初[1] 

机构地区：[1]云南大学应用化学系,昆明650091

出　　处：《高等学校化学学报》2004年第2期294-296,共3页Chemical Journal of Chinese Universities

基　　金：云南省自然科学基金 (批准号 :1999B0 0 0 5 M);南开大学元素有机化学国家重点实验室开发基金资助

摘　　要：Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.

关 键 词：苯甲酰基脲类几丁质抑制剂 合成 百菌清 农药 昆虫生长调节剂 

分 类 号：TQ453.2[化学工程—农药化工]