Ⅰ期非小细胞肺癌淋巴结微转移与预后关系的Meta分析  

Meta-Analysis of Relationship between Lymph Node Micrometastasis and Prognosis in Stage ⅠNon-Small Cell Lung Cancer Patients

作　　者：郑智[1] 潘铁成[1] 李军[1] 陈涛[1] 宋定伟[1] 易军[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院胸心外科,湖北武汉430030

出　　处：《癌症》2004年第2期185-188,共4页Chinese Journal of Cancer

摘　　要：背景与目的:淋巴结转移是影响非小细胞肺癌预后的重要因素,而淋巴结微转移对预后有何影响,各研究机构报道不一。本研究将有关Ⅰ期非小细胞肺癌淋巴结微转移与预后关系的文献进行综合,以探讨两者间的联系。方法:利用Meta分析的方法综合国内外1980～2002年关于Ⅰ期非小细胞肺癌淋巴结微转移与预后关系的文献。结果:符合要求纳入分析的文献共8篇,累计病例536例。常规病检阴性淋巴结微转移的检测率为3.4%～28.9%,阳性病例的比例高达20%～70%。Ⅰ期非小细胞肺癌淋巴结微转移患者与非微转移患者的3、5年生存率比较,其合并ORs值分别为4.16(95%CI=2.32～7.46)和3.57(95%CI=2.30～5.53)(P<0.01)。结论:淋巴结微转移是影响Ⅰ期非小细胞肺癌患者术后生存率的重要因素。BACKGROUND &OBJECTIVE: Lymph node metastasis is an important factor for prognosis of non small cell lung cancer (NSCLC). There were different opinions about what effect does lymph node micrometastasis have on prognosis. This study was designed to collect literatures of lymph node micrometastasis and prognosis in stage ⅠNSCLC patients, in order to investigate their relationship. METHODS: The results from eight literatures on lymph node micrometastasis and prognosis from 1980 to 2002 were analyzed synthetically by meta analysis. The cumulative cases were 536 NSCLC patients with stage Ⅰdisease. RESULTS: The detection rate of lymph node micrometastasis ranged from 3.4%to 28.9%, and the rate of positive cases ranged from 20%to 70%. The 3 , 5 year over survival rate for positive lymph node micrometastasis patients was worse than those of negative lymph node micrometastasis patients: odd ratios (ORs) were 4.16 (95%CI:2.32-7.46) and 3.57 (95%CI:2.30-5.53), respectively (P< 0.01). CONCLUTION: Positive lymph node micrometastasis may be an adverse factor for post operative prognosis of NSCLC stage Ⅰpatients.

关 键 词：I期非小细胞肺癌 淋巴结微转移 预后 META分析 

分 类 号：R734.2[医药卫生—肿瘤]