人口腔鳞癌演变过程中HLA-DR表达改变的研究  

Analysis of HLA-DR expression in relation to the development of oral squamous cell carcinoma

作　　者：张少平[1] 李龙江[1] 黄欣[1] 佟猛[1] 

机构地区：[1]四川大学华西口腔医院口腔颌面外科,成都610041

出　　处：《实用口腔医学杂志》2004年第1期31-34,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金资助No.3970 0 1 6 2资助

摘　　要：目的 :观察HLA DR在口腔鳞癌发生、发展过程中表达的改变并探讨其临床意义。方法 :采用免疫组织化学的方法检测了 2 6例正常口腔黏膜、8例口腔黏膜白斑、3 2例口腔鳞癌原发灶及 15例颈淋巴结转移灶标本内HLA DR的表达。结果 :口腔鳞癌原发灶与正常口腔黏膜HLA DR的表达存在有显著性差异 (P <0 .0 5) ,其余各组间未见有此差异 ;鳞癌原发灶HLA DR的表达除与局部淋巴细胞浸润有显著性关系外与其余各临床病理资料间均无明显关系。结论 :HLAObjective: To observe HLA DR expression in different s tages of oral squamous cell carcinoma (OSCC) and to study the clinic significan ce of the abnormal HLA DR expression in primary OSCC. Method: HLA DR expression was detected by immunohistochemistry method in 26 cas es of histologically normal oral epithelia, 8 leukoplakia, 32 primary focuses an d 12 metastasis focuses of OSCC. Results: HLA DR express ion in primary OSCC focuses was significantly higher than that in normal epithel ium( P <0.05).and closely associated with the lymphocytes infiltration. There was no statistic difference between each two of the other groups ( P >0.05). Conclusion: Although HLA DR expression is frequently obs erved in the development of OSCCs, it can not be regarded as one of the indepen dent prognosis factors.

关 键 词：人口腔鳞癌 HLA-DR 免疫学 预后 淋巴结转移 

分 类 号：R739.8[医药卫生—肿瘤]