原发胆汁性肝硬化存活率依赖于腹水和(或)外周水肿的进展:一项阶段性预后模型  

Survival following the development of ascites and/or peripheral oedema in primary biliary cirrhosis: A staged prognostic model

作　　者：Carpenter J.R. Rigamonti C. A.K. Burroughs 李宏宇 

机构地区：[1]Liver Transplantation and Hepatobiliary Medicine, Royal FreeHospital, Pond Street,Hampstead,LondonNW3 2QG, United Kingdom

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第2期62-62,共1页Core Journals in Gastroenterology

摘　　要：Objective. Current prognostic models in primary biliary cirrhosis (PBC) have low precision, partly due to the restricted inclusion criteria of some cohorts used for modelling but also because of the prolonged natural course of the disease. It is hypothesized that better precision could be achieved with a staged model, using ascites or peripheral oedema as a new startingpoint for prediction. Material and methods. The study was based on an established database of 289 consecutive patients, followed between 1977 and 1998. Stepwise Cox regression was used to construct a staged model based on 143 patients who first developed ascites (n = 111) or peripheral oedema (n = 32) at entry or during subsequent follow-up. The model was compared with published models using graphical methods and receiver operating characteristics (ROCs). Results. Mean time from clinical diagnosis of ascites or peripheral oedema to death was 3.1 years. The following variables had independent prognostic significance: log10(bilirubin) (p < 0.001), albumin (p < 0.001), age (p < 0.001) and history of encephalopathy (p < 0.001). Goodness of fit showed that the survival probabilities predicted by the Ascites Stage Model fitted well with the observed data. The Ascites Stage Model (ROC 0.8324 (SE 0.0348)) was a better predictor of survival than the Mayo long-term model (ROC 0.7833 (SE 0.0397)), the Mayo Repeated Patient Visits Model (ROC 0.7779 (SE 0.0399)) and the Royal Free PBC Prognostic Model (ROC 0.7785 (SE 0.0396)). Conclusions. The Ascites Stage Model gives a better survival estimate for PBC patients once they have developed ascites or peripheral oedema compared with the current models, and demonstrates an advantage of staged models in diseases with a prolonged natural history.Objective. Current prognostic models in primary biliary cirrhosis (PBC) have low precision, partly due to the restricted inclusion criteria of some cohorts used for modelling but also because of the prolonged natural course of the disease. It is hypothesized that better precision could be achieved with a staged model, using ascites or peripheral oedema as a new startingpoint for prediction. Material and methods. The study was based on an established database of 289 consecutive patients, followed between 1977 and 1998. Stepwise Cox regression was used to construct a staged model based on 143 patients who first developed ascites (n = 111) or peripheral oedema (n = 32) at entry or during subsequent follow-up. The model was compared with published models using graphical methods and receiver operating characteristics (ROCs). Results. Mean time from clinical diagnosis of ascites or peripheral oedema to death was 3.1 years. The following variables had independent prognostic significance: log10(bilirubin) (p < 0.001), albumin (p < 0.001), age (p < 0.001) and history of encephalopathy (p < 0.001). Goodness of fit showed that the survival probabilities predicted by the Ascites Stage Model fitted well with the observed data. The Ascites Stage Model (ROC 0.8324 (SE 0.0348)) was a better predictor of survival than the Mayo long-term model (ROC 0.7833 (SE 0.0397)), the Mayo Repeated Patient Visits Model (ROC 0.7779 (SE 0.0399)) and the Royal Free PBC Prognostic Model (ROC 0.7785 (SE 0.0396)). Conclusions. The Ascites Stage Model gives a better survival estimate for PBC patients once they have developed ascites or peripheral oedema compared with the current models, and demonstrates an advantage of staged models in diseases with a prolonged natural history.

关 键 词：胆汁性肝硬化 外周水肿 存活时间 临床诊断 预后意义 作图法 吻合度 选择标准 

分 类 号：R575.2[医药卫生—消化系统]