肝癌前病变发生发展及恶变相关信号通路研究进展  

Progress of Signal Pathways Related to the Occurrence, Development and Malignant Change of Hepatocellular Carcinoma

作　　者：董夏 焦佩娟 芮冉 孟博博 潘艳芳[2] 方艳[2] 李宏[2] 应小平[2] DONG Xia;JIAO Peijuan;RUI Ran;MENG Bobo;PAN Anfang;FANG Yan;LI Hong;YING Xiaoping(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi Province,China;Department of Pathology,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi Province,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学病理学教研室,陕西咸阳712046

出　　处：《吉林中医药》2019年第5期691-695,共5页Jilin Journal of Chinese Medicine

基　　金：国家自然科学基金青年项目(81703842);陕西省科技厅项目(2017SF-306);陕西省中管局科研计划项目(JCMS032)

摘　　要：肝癌是消化系统常见的恶性肿瘤之一,具有病情隐匿、预后凶险等临床特征,在我国发生率较高。肝癌前病变是指使肝脏发生恶变可能的良性病变,若长期不愈则可能转变为原发性肝癌。近年来大量研究表明,肝癌的发生与多种细胞信号转导通路密切相关。文章总结了Hippo-YAP/TAZ、Wnt/β-catenin、Hedgehog、Notch、JAK-STAT等信号通路与肝癌前病变相关性的最新研究进展及其在肝癌前病变发展过程中所发挥的重要作用,希望能够为临床及基础研究提供理论参考。Hepatocellular carcinoma is one of the most common malignant tumors in digestive system,with the characteristics of insidious condition and dangerous prognosis,and has a high incidence in China.Precancerous lesions of the liver refer to benign lesions that may cause malignant transformation of the liver,if they has not heal for a long time,they may become primary liver cancer.In recent year,a large number of studies have shown that the occurrence of hepatocellular carcinoma is closely related to a variety of cellular signal transduction pathways.This paper summarizes the latest research progress of Hippo-YAP/TAZ,Wnt/β-catenin,Hedgehog,Notch,JAK-STAT signaling pathways and their important roles in the development of precancerous lesions of liver.Hope to provide theoretical reference for clinical and basic research.

关 键 词：肝癌前病变 信号通路 研究进展 

分 类 号：R735.7[医药卫生—肿瘤]