壮肝逐瘀煎对肝纤维化大鼠血清学的影响  

The Study of Zhuangganzhuyu Jian on Serum Markers in the Model of Liver Fibrosis.

作　　者：林寿宁[1] 黄贵华[1] 王振常[2] 

机构地区：[1]广西中医学院瑞康医院,南宁530001 [2]广西中医学院,南宁530001

出　　处：《实用中西医结合临床》2004年第1期1-3,7,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广西壮族自治区自然科学基金资助项目(NO:桂科0229047)

摘　　要：目的:通过大鼠肝纤维化动物模型,研究壮肝逐瘀煎防治肝纤维化的作用效果及其机理。方法:采用四氯化碳(CCL4)复合因素大鼠肝纤维化模型,予壮肝逐瘀煎灌胃,观察其对肝纤四项及形态学的影响,以大黄蟅虫丸为对照。结果:壮肝逐瘀煎显著降低大鼠血清中HA、LN、IV-C、PC-Ⅲ的水平,并能减轻肝脏炎症及纤维化程度。结论:壮肝逐瘀煎具有抗肝纤维化作用。Objective:To investigate the effect and mechanisim of ZhuangGanZhuYuJian in treatment of liver fibrosis in rat model. Methods:After making the model with Carbon tetrachloride combined factors and treated with ZhuangGanZhuYuJian. The indexes of hepatofibrosis and pathology of liver were observed,using DaHuangZheChongWan as control. Results:The serum level of HA,LN,IV-C and PC-Ⅲ were significantly decreased,and the formation of liver fibrosis was successfully ameliorated by the ZhuangGanZhuYuJian.ConclusionrZhuangGanZhuYuJian could retain the progression of liver fibrosis.

关 键 词：壮肝逐瘀煎 肝纤维化 血清学 动物模型 

分 类 号：R575.2[医药卫生—消化系统]