拓扑替康联合顺铂治疗晚期非小细胞肺癌28例近期疗效观察  

Combination Chemotherapy with Topotecan and Cisplatin in the Treatment of28 Cases of Advanced Non-small Cell Lung Cancer

作　　者：张成辉[1] 任中海[1] 仝运科[1] 

机构地区：[1]南阳市中心医院肿瘤科,河南南阳473000

出　　处：《河南肿瘤学杂志》2004年第1期39-40,共2页Henan Journal of Oncology

摘　　要：目的　观察拓扑替康联合顺铂治疗晚期非小细胞肺癌的近期疗效。方法　拓扑替康 1mg/m2 ,静脉点滴 ,第 1～ 5天 ;PDD 3 0mg/m2 ,静脉点滴 ,第 1～ 3天。每 2 1天为 1个周期 ,连用 2个周期后评价疗效。结果　CR 2例 ,PR 13例 ,总有效率CR +PR 5 3 6%。本方案主要的毒副反应是骨髓抑制和胃肠道反应。结论　拓扑替康联合顺铂是一个安全、有效的治疗晚期非小细胞肺癌的临床方案。Objective To observe the recent effect of combination chemotherapy with topotecan(TPT) and cisplatin(PDD) in the treatment of patients with advanced non_small cell lung cancer.Methods Topotecan(TPT) was 1 mg/m 2 ivgtt,d1～5. PDD was 30 mg/m 2 ivgtt,d1～3.The schedule was repeated every 21 days, with at least two cycles.Results The complete response was observed in 2 cases, and partial response was observed in 13 cases. The overall response rate (RR) was 53.6%. The major toxicities were myelosuppression and gastrointestinal reaction.Conclusion The regimen is effective and safe in the treatment of patients with advanced non_small cell lung cancer.

关 键 词：拓扑替康 联合用药 顺铂 药物治疗 晚期非小细胞肺癌 毒副反应 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]